Evidence map›Paper›PMID 36768287›Full record

ArticleInternational journal of molecular sciences2023

Does the Blood-Brain Barrier Integrity Change in Regard to the Onset of Fetal Growth Restriction?

Natalia Misan, Sławomir Michalak, Katarzyna Kapska, Krystyna Osztynowicz, Mariola Ropacka-Lesiak, Katarzyna Kawka-Paciorkowska

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natalia MisanDepartment of Perinatology and Gynecology, Poznan University of Medical Sciences, 60-535 Poznan, Poland.ORCID 0000-0003-3185-5020
Sławomir MichalakDepartment of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Katarzyna KapskaDepartment of Perinatology and Gynecology, Poznan University of Medical Sciences, 60-535 Poznan, Poland.
Krystyna OsztynowiczDepartment of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, 60-355 Poznan, Poland.ORCID 0000-0003-4782-1474
Mariola Ropacka-LesiakDepartment of Perinatology and Gynecology, Poznan University of Medical Sciences, 60-535 Poznan, Poland.
Katarzyna Kawka-PaciorkowskaDepartment of Perinatology and Gynecology, Poznan University of Medical Sciences, 60-535 Poznan, Poland.ORCID 0000-0003-4674-0496

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to determine whether early-onset and late-onset fetal growth restriction (FGR) differentially affects the blood-brain barrier integrity. Furthermore, the purpose of the study was to investigate the relationship between the blood-brain barrier breakdown and neurological disorders in FGR newborns. To evaluate the serum tight junction (TJ) proteins and the placental TJ proteins expression, an ELISA method was used. A significant difference in serum OCLN concentrations was noticed in pregnancies complicated by the early-onset FGR, in relation to the intraventricular hemorrhage (IVH) occurrence in newborns. No significant differences in concentrations of the NR1 subunit of the

Indexed as

Blood-Brain BarrierFetal Growth RetardationNervous System DiseasesPlacentaBiomarkersBrainCerebral HemorrhageFemaleHumansInfant, NewbornNM23 Nucleoside Diphosphate KinasesOccludinPregnancyS100 Calcium Binding Protein beta SubunitZonula Occludens-1 ProteinBiomarkersNM23 Nucleoside Diphosphate KinasesNME1 protein, humanOccludinOCLN protein, humanS100B protein, humanS100 Calcium Binding Protein beta SubunitTJP1 protein, humanZonula Occludens-1 Proteinblood–brain barrierbrain damageearly-onset fetal growth restrictionfetal hypoxialate-onset fetal growth restrictionplacental insufficiencytight junction proteinstight junctions

Identifiers

PMID36768287
PMCPMC9916066

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.