ArticleInternational journal of molecular sciences2023
Definition and Characterization of SOX11-Derived T Cell Epitopes towards Immunotherapy of Glioma.
Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Review
- New prognostic features and personalized treatment strategies of mitochondrial related genes in colorectal cancer patients.Frontiers in pharmacology · 2025Article
- Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells.BMC biology · 2024Article
- SOX on tumors, a comfort or a constraint?Cell death discovery · 2024Review
- Bioactive Peptides in Human Health and Disease.International journal of molecular sciences · 2023Article
- Novel prognostic features and personalized treatment strategies for mitochondria-related genes in glioma patients.Frontiers in endocrinology · 2023Article
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Authors and funding
10 authors.
Funding
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Abstract
The transcription factor SOX11 is a tumor-associated antigen with low expression in normal cells, but overexpression in glioblastoma (GBM). So far, conventional surgery, chemotherapy, and radiotherapy have not substantially improved the dismal prognosis of relapsed/refractory GBM patients. Immunotherapy is considered a promising strategy against GBM, but there is a fervent need for better immunotargets in GBM. To this end, we performed an in silico prediction study on SOX11, which primarily yielded ten promising HLA-A*0201-restricted peptides derived from SOX11. We defined a novel peptide FMACSPVAL, which had the highest score according to in silico prediction (6.02 nM by NetMHC-4.0) and showed an exquisite binding affinity to the HLA-A*0201 molecule in the peptide-binding assays. In the IFN-γ ELISPOT assays, FMACSPVAL demonstrated a high efficiency for generating SOX11-specific CD8
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