Evidence map›Paper›PMID 36768219›Full record

ArticleInternational journal of molecular sciences2023

Antifibrotic Soluble Thy-1 Correlates with Renal Dysfunction in Chronic Kidney Disease.

Anja Saalbach, Ulf Anderegg, Ralph Wendt, Joachim Beige, Anette Bachmann, Nora Klöting, Matthias Blüher, Ming-Zhi Zhang, Raymond C Harris, Michael Stumvoll and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anja SaalbachDepartment of Dermatology, Venereology and Allergology, University of Leipzig Medical Center, 04103 Leipzig, Germany.ORCID 0000-0002-1084-3875
Ulf AndereggDepartment of Dermatology, Venereology and Allergology, University of Leipzig Medical Center, 04103 Leipzig, Germany.ORCID 0000-0002-3993-9192
Ralph WendtHospital St. Georg, Division of Nephrology and Kuratorium for Dialysis and Transplantation, 04129 Leipzig, Germany.ORCID 0000-0003-1600-6581
Joachim BeigeHospital St. Georg, Division of Nephrology and Kuratorium for Dialysis and Transplantation, 04129 Leipzig, Germany.
Anette BachmannMedical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.
Nora KlötingHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany.
Matthias BlüherMedical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.ORCID 0000-0003-0208-2065
Ming-Zhi ZhangDivision of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA.
Raymond C HarrisDivision of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA.
Michael StumvollMedical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.
Anke TönjesMedical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.
Thomas EbertMedical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.ORCID 0000-0003-1683-9276

Funding

Deutsche Forschungsgemeinschaft SA 863/9-1
6 · The paper itself

Abstract

Kidney fibrosis is a major culprit in the development and progression of chronic kidney disease (CKD), ultimately leading to the irreversible loss of organ function. Thymocyte differentiation antigen-1 (Thy-1) controls many core functions of fibroblasts relevant to fibrogenesis but is also found in a soluble form (sThy-1) in serum and urine. We investigated the association of sThy-1 with clinical parameters in patients with CKD receiving hemodialysis treatment compared to individuals with a preserved renal function. Furthermore, Thy-1 tissue expression was detected in a mouse model of diabetic CKD (eNOS

Indexed as

Renal Insufficiency, ChronicAnimalsCreatinineFibroblastsFibrosisKidneyMiceThy-1 AntigensCreatinineThy-1 Antigenschronic kidney diseasefibrosisrenal dysfunctionThy-1

Identifiers

PMID36768219
PMCPMC9916214

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.