Evidence map›Paper›PMID 36768196›Full record

ArticleInternational journal of molecular sciences2023

Dietary-Induced Bacterial Metabolites Reduce Inflammation and Inflammation-Associated Cancer via Vitamin D Pathway.

Caitlin O'Mahony, Adam Clooney, Siobhan F Clarke, Mònica Aguilera, Aisling Gavin, Donjete Simnica, Mary Ahern, Aine Fanning, Maurice Stanley, Raul Cabrera Rubio and 12 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
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  6. Article
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  10. Review
  11. The impact of vitamin D on cancer: A mini review.The Journal of steroid biochemistry and molecular biology · 2023
    Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Caitlin O'MahonyAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.
Adam ClooneyAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.
Siobhan F ClarkeAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.ORCID 0000-0002-7050-3661
Mònica AguileraAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.ORCID 0000-0003-0763-7947
Aisling GavinAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.
Donjete SimnicaAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.
Mary AhernAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.
Aine FanningAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.ORCID 0000-0001-8050-1769
Maurice StanleyAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.
Raul Cabrera RubioAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.ORCID 0000-0003-3652-9558
Elaine PattersonAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.
Tatiana MarquesAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.
Rebecca WallAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.
Aileen HoustonAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.ORCID 0000-0003-1362-5256
Amr MahmoudNational Cancer Screening Service, Cork University Hospital, T12 DC4A Cork, Ireland.
Michael W BennettNational Cancer Screening Service, Cork University Hospital, T12 DC4A Cork, Ireland.
Catherine StantonAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.ORCID 0000-0002-6724-7011
Marcus J ClaessonAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.ORCID 0000-0002-5712-0623
Paul D CotterAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.ORCID 0000-0002-5465-9068
Fergus ShanahanAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.
Susan A JoyceAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.ORCID 0000-0003-4771-3123
Silvia MelgarAPC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland.ORCID 0000-0001-7463-3343

Funding

Science Foundation Ireland SFI-07/CE/B1368 and SFI-12/RC/2273
6 · The paper itself

Abstract

Environmental factors, including westernised diets and alterations to the gut microbiota, are considered risk factors for inflammatory bowel diseases (IBD). The mechanisms underpinning diet-microbiota-host interactions are poorly understood in IBD. We present evidence that feeding a lard-based high-fat (HF) diet can protect mice from developing DSS-induced acute and chronic colitis and colitis-associated cancer (CAC) by significantly reducing tumour burden/incidence, immune cell infiltration, cytokine profile, and cell proliferation. We show that HF protection was associated with increased gut microbial diversity and a significant reduction in Proteobacteria and an increase in Firmicutes and

Indexed as

ColitisInflammatory Bowel DiseasesNeoplasmsAnimalsBacteriaBile Acids and SaltsColonDextran SulfateDiet, High-FatInflammationMiceMice, Inbred C57BLVitamin DBile Acids and SaltsDextran SulfateVitamin Dbile acidscolitiscolitis-associated cancerhigh-fat dietinflammationproliferationvitamin D

Identifiers

PMID36768196
PMCPMC9914969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.