Evidence map›Paper›PMID 36768163›Full record

ArticleInternational journal of molecular sciences2023

Mutations in Complex I of the Mitochondrial Electron-Transport Chain Sensitize the Fruit Fly (

Luke A Borchardt, Amanda R Scharenbrock, Zachariah P G Olufs, David A Wassarman, Misha Perouansky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luke A BorchardtDepartment of Anesthesiology, University of Wisconsin-Madison, Madison, WI 53792, USA.ORCID 0000-0002-1237-251X
Amanda R ScharenbrockDepartment of Anesthesiology, University of Wisconsin-Madison, Madison, WI 53792, USA.
Zachariah P G OlufsDepartment of Anesthesiology, University of Wisconsin-Madison, Madison, WI 53792, USA.ORCID 0000-0002-7812-8261
David A WassarmanDepartment of Medical Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA.
Misha PerouanskyDepartment of Anesthesiology, University of Wisconsin-Madison, Madison, WI 53792, USA.ORCID 0000-0003-1759-5277

Funding

Anesthetic-Induced Neurotoxicity: Molecular Pathways and Genetic Risk FactorsR01GM134107 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WASSARMAN, DAVID · 2020 to 2023
$1.4M
NIGMS NIH HHS R01 GM134107
6 · The paper itself

Abstract

The mitochondrial electron transport chain (mETC) contains molecular targets of volatile general anesthetics (VGAs), which places carriers of mutations at risk for anesthetic complications. The

Indexed as

AnestheticsAnesthetics, InhalationIsofluraneAnimalsDrosophilaDrosophila melanogasterElectronsElectron Transport Complex IEtherEthersEthyl EthersHalothaneMammalsMutationAnestheticsAnesthetics, InhalationElectron Transport Complex IEtherEthersEthyl EthersHalothaneIsofluraneanoxiaComplex Ielectron transport chainhalothaneisofluranemitochondriamutationstoxicityvolatile anesthetics

Identifiers

PMID36768163
PMCPMC9915120

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.