Evidence map›Paper›PMID 36767724›Full record

ArticleInternational journal of environmental research and public health2023

Cognitive and Mood Effect of Alpha-Lipoic Acid Supplementation in a Nonclinical Elder Sample: An Open-Label Pilot Study.

Gianpaolo Antonio Basile, Fiammetta Iannuzzo, Francesco Xerra, Giovanni Genovese, Gianluca Pandolfo, Clemente Cedro, Maria Rosaria Anna Muscatello, Antonio Bruno

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Alpha-lipoic acid: A promising pharmacotherapy seen through the lens of kidney diseases.Current research in pharmacology and drug discovery · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Gianpaolo Antonio BasileDepartment of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Via Consolare Valeria 1, Contesse, 98125 Messina, Italy.
Fiammetta IannuzzoDepartment of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Via Consolare Valeria 1, Contesse, 98125 Messina, Italy.ORCID 0000-0002-8576-6560
Francesco XerraDepartment of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Via Consolare Valeria 1, Contesse, 98125 Messina, Italy.
Giovanni GenovesePsychiatry Unit, Polyclinic Hospital University of Messina, Via Consolare Valeria 1, Contesse, 98125 Messina, Italy.ORCID 0000-0002-4984-7208
Gianluca PandolfoDepartment of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Via Consolare Valeria 1, Contesse, 98125 Messina, Italy.ORCID 0000-0002-9978-2481
Clemente CedroDepartment of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Via Consolare Valeria 1, Contesse, 98125 Messina, Italy.
Maria Rosaria Anna MuscatelloDepartment of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Via Consolare Valeria 1, Contesse, 98125 Messina, Italy.ORCID 0000-0001-7271-6989
Antonio BrunoDepartment of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Via Consolare Valeria 1, Contesse, 98125 Messina, Italy.ORCID 0000-0002-8789-1680
University of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMemory disorders are common among elder people, and nonclinical cognitive decline is commonly experienced with age. Preclinical investigations have explored the possible role of alpha-lipoic acid (ALA), a known antioxidant compound abundant in vegetables and animal tissues, in reducing oxidative stress in the aging brain and preventing cognitive decline. However, clinical evidence is limited, and the few existing results are contrasting. In addition, while most of the existing trials have been focused on the effects of ALA administration in Alzheimer's disease (AD) or other types of dementia, studies evaluating its effects on nonclinical elder population are still missing.

methodsIn the present open-label, pilot study, fifteen elder patients (mean age: 84.5 ± 5.77) received ALA at a daily dose of 600 mg/day for 12 weeks. General cognitive function, executive function, and mood symptom assessment were carried out at baseline and at the endpoint.

resultsOverall, ALA administration was generally well-tolerated (only one dropout due to gastrointestinal side effects). However, no statistically significant effects either on cognitive function, executive function, or mood were found.

conclusionsDespite several limitations, our study found no evidence of positive effects on cognition and mood after ALA administration in elder people without the diagnosis of AD or cognitive impairment. Further clinical trials are needed to better investigate ALA effectiveness on cognition and mood in elder subjects.

Indexed as

Alzheimer DiseaseCognition DisordersThioctic AcidCognitionDietary SupplementsHumansPilot ProjectsThioctic AcidALAalpha-lipoic acidcognitionexecutive functionsmemorynutraceutics

Identifiers

PMID36767724
PMCPMC9916195
OpenAlexW4318474679

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.