ReviewInternational journal of environmental research and public health2023
Iron, Zinc, Copper, Cadmium, Mercury, and Bone Tissue.
Review in International journal of environmental research and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Pooled it
- Meta-analysis of the Relationship Between Zinc and Copper in Patients with Osteoarthritis.Biological trace element research · 2025Pooled it
- Toxicological evidence that methylmercury exposure amplifies bone destruction and systemic impact associated with apical periodontitis in rats.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Circulating Elements in the Bloodstream of Growing Foals: Focus on Heavy Metals and Bone Remodeling Across Growth Stages.Biological trace element research · 2026Article
- Biomedical potential of bovine-derived hydroxyapatite: synthesis strategies, characterization and applications.RSC advances · 2026Review
- Could Trace Elements be Linked to Fracture Healing Acceleration in Traumatic Brain Injury-related Skeletal Polytrauma?Biological trace element research · 2026Article
- Research advances of copper homeostasis and cuproptosis in orthopedic diseases.Cell death discovery · 2026Review
- Research Progress of Cuproptosis in Orthopaedics: Opportunities and Challenges.Journal of cellular and molecular medicine · 2026Review
- The Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review.Biological trace element research · 2026Article
- Review
- Cuproptosis promotes inflammatory osteolysis via GYS1-mediated glycogen metabolism.International journal of oral science · 2026Article
- Cuproptosis and Diabetic Osteoporosis: Mechanisms and Therapeutic Prospects.International journal of molecular sciences · 2026Review
- Protective effects of dietary Cucurbita pepo on oxidative damage, histopathological alterations, and endoplasmic reticulum stress in the brain and gills of Oreochromis niloticus exposed to trace elements.Veterinary research communications · 2025Article
- Use of Amalgam and Composite Restorations Among 12-Year-Old Children in Israel: A Retrospective Study.Biomimetics (Basel, Switzerland) · 2025Article
- Metal-Based Categorization of Recent Metal Organic Frameworks with Application in Bone Disease Treatment.ACS biomaterials science & engineering · 2025Review
- Nano Calcium from Marine Fish Bones via High-Energy Ball Milling: A Potential Natural Supplement for Bone Health.Journal of bone metabolism · 2025Article
- Carnosine Biofunctionalized Hydroxyapatite Induces Copper-Driven Osteogenesis and Angiogenesis, Strengthening Its Bone Regenerative Capacities.ACS biomaterials science & engineering · 2025Article
- Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.Medicine · 2025Article
- Organic Glycinate Trace Minerals Improve Hatchability, Bone and Eggshell Breaking Strength, and Mineral Uptake During Late Laying Cycle in Layer Breeders.Veterinary sciences · 2025Article
- Metal-organic frameworks for biomedical applications: bridging materials science and regenerative medicine.RSC advances · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The paper presents the current understanding on the effects of five metals on bone tissue, namely iron, zinc, copper, cadmium, and mercury. Iron, zinc, and copper contribute significantly to human and animal metabolism when present in sufficient amounts, but their excess or shortage increases the risk of developing bone disorders. In contrast, cadmium and mercury serve no physiological purpose and their long-term accumulation damages the osteoarticular system. We discuss the methods of action and interactions between the discussed elements as well as the concentrations of each element in distinct bone structures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.