Evidence map›Paper›PMID 36767310›Full record

ArticleInternational journal of environmental research and public health2023

Sustained Cytotoxic Response of Peripheral Blood Mononuclear Cells from Unvaccinated Individuals Admitted to the ICU Due to Critical COVID-19 Is Essential to Avoid a Fatal Outcome.

Guiomar Casado-Fernández, Magdalena Corona, Montserrat Torres, Adolfo J Saez, Fernando Ramos-Martín, Mario Manzanares, Lorena Vigón, Elena Mateos, Francisco Pozo, Inmaculada Casas and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Guiomar Casado-FernándezImmunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0001-5835-896X
Magdalena CoronaFaculty of Sciences, Universidad de Alcalá, 28805 Madrid, Spain.ORCID 0000-0002-6553-0171
Montserrat TorresImmunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Adolfo J SaezHematology and Hemotherapy Service, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
Fernando Ramos-MartínImmunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Mario ManzanaresImmunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0002-7878-4007
Lorena VigónImmunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Elena MateosImmunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Francisco PozoRespiratory Viruses Service, National Center of Microbiology, Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0003-1828-733X
Inmaculada CasasRespiratory Viruses Service, National Center of Microbiology, Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0003-1840-1198
Valentín García-GutierrezHematology and Hemotherapy Service, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.ORCID 0000-0003-4752-0815
Sara Rodríguez-MoraImmunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0003-2467-116X
Mayte CoirasImmunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0001-6464-5770
Instituto de Salud Carlos III · ESInstituto Ramón y Cajal de Investigación Sanitaria · ESUniversidad de Alcalá · ES

Funding

Tyrosine Kinase inhibition: The New Front in HIV Cure EffortsR01AI143567 · NIAID · UNIVERSITY OF UTAH · PI COIRAS, MAYTE, PLANELLES, VICENTE · 2019 to 2023
$2.3M
NIAID NIH HHS R01 AI143567
6 · The paper itself

Abstract

The main objective of this study was to determine the influence of the cytotoxic activity of peripheral blood mononuclear cells (PBMCs) on the outcome of unvaccinated individuals with critical COVID-19 admitted to the ICU. Blood samples from 23 individuals were collected upon admission and then every 2 weeks for 13 weeks until death (Exitus group) (

Indexed as

Antineoplastic AgentsCOVID-19BiomarkersHospitalizationHumansIntensive Care UnitsInterleukin-15Leukocytes, MononuclearSARS-CoV-2Antineoplastic AgentsBiomarkersInterleukin-15COVID-19cytotoxic responseIL-15immune responseSARS-CoV-2

Identifiers

PMID36767310
PMCPMC9915056
OpenAlexW4317538206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.