ArticleInternational journal of environmental research and public health2023
Association between Body Mass Index and Diabetes Mellitus Are Mediated through Endogenous Serum Sex Hormones among Menopause Transition Women: A Longitudinal Cohort Study.
Article in International journal of environmental research and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 6 citations in OpenAlex.
- Association between body roundness index trajectories and the incidence of diabetes mellitus: a perspective from the China health and retirement longitudinal study.Lipids in health and disease · 2025Article
- Association of relative fat mass with the incidence of type 2 diabetes: over a decade follow-up from the TLGS.International journal of obesity (2005) · 2025Article
- Impact of adiposity indices changes across the lifespan on risk of diabetes in women: trajectory modeling approach.BMC public health · 2024Article
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6 authors at 1 institution in 1 country.
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Abstract
objectiveTo explore whether and to what extent endogenous sex hormones mediate the association between overweight and diabetes risk in menopausal transition women.
methodsPremenopausal women were from the Study of Women's Health Across the Nation, with measurements of serum sex hormone including sex hormone binding globulin (SHBG), testosterone (T), estradiol (E2), follicle-stimulating hormone (FSH), and dehydroepiandrosterone sulfate (DHAS) in first postmenopausal follow-up. At the last postmenopausal follow-up, hyperglycemia status was confirmed. The partial least squares (PLS) regression method was used to extract hormonal signals associated with body mass index (BMI). Hyperglycemia was defined as individuals with prediabetes or diabetes; overweight was defined as BMI ≥ 25 kg/m
resultsThe longitudinal study included 1438 normal glucose women with a baseline mean age (SD) of 46.5 (2.6) years and a mean follow-up period of 9.9 years. During the follow-up period, 145 (10.1) cases of hyperglycemia occurred. Compared with normal-weight participants, overweight women were associated with a higher hyperglycemia risk during the transition period (OR = 4.06, 95% CI: 2.52 to 6.80). Overweight women had higher T, E2, and lower SHBG, FSH, and DAHS concentrations (β = 0.26, 0.38, -0.52, -0.52, and -0.13,
conclusionsSex hormones mediated the association of overweight and diabetes risk in menopause transition women. SHBG and FSH have the dominant mediation effect.
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