Evidence map›Paper›PMID 36766896›Full record

ArticleHealthcare (Basel, Switzerland)2023

Metformin Therapy and Breast Cancer Incidence in the Ha'il Region.

Mhdia Osman, Taif Muqbel, Ahad Abduallh, Shuruq Alanazi, Nasrin E Khalifa, Weam M A Khojali, Halima Mustafa Elagib, Weiam Hussein, Marwa H Abdallah

Abstract read
In one paragraph

Article in Healthcare (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mhdia OsmanDepartment of Clinical Pharmacy, Faculty of Pharmacy, University of Ha'il, P.O. Box 2440, Ha'il 55476, Saudi Arabia.ORCID 0000-0003-0461-8775
Taif MuqbelStudent College of Pharmacy, University of Ha'il, Ha'il 55476, Saudi Arabia.
Ahad AbduallhStudent College of Pharmacy, University of Ha'il, Ha'il 55476, Saudi Arabia.
Shuruq AlanaziStudent College of Pharmacy, University of Ha'il, Ha'il 55476, Saudi Arabia.
Nasrin E KhalifaDepartment of Pharmaceutics, Faculty of Pharmacy, University of Ha'il, Ha'il 55476, Saudi Arabia.ORCID 0000-0001-9300-3515
Weam M A KhojaliDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ha'il, Ha'il 55476, Saudi Arabia.ORCID 0000-0002-7962-1429
Halima Mustafa ElagibDepartment of Pharmacology, Faculty of Medicine, University of Ha'il, Ha'il 55476, Saudi Arabia.ORCID 0000-0002-7291-7649
Weiam HusseinDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ha'il, Ha'il 55476, Saudi Arabia.ORCID 0000-0003-1782-7349
Marwa H AbdallahDepartment of Pharmaceutics, Faculty of Pharmacy, University of Ha'il, Ha'il 55476, Saudi Arabia.ORCID 0000-0001-6670-3903

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetformin is a drug used to treat patients with type 2 diabetes, especially those who suffer from obesity. It is also used in the treatment of women with polycystic ovary syndrome (PCOS). This disease is related to insulin resistance and multiplied blood sugar ranges. Furthermore, it has been established that the use of metformin improves the menstrual cycles and ovulation rates of these women.

methodsA structured questionnaire was conducted to determine the prevalence of breast cancer among women using metformin in the Ha'il region.

resultThe incidence of breast cancer among women using metformin in the Ha'il region is very low. Thus, it can be said that breast cancer cases declined among diabetics taking metformin. This means that metformin use is associated with a lower risk of breast cancer in women with type 2 diabetes, even in cases where these women have a family history of breast cancer.

conclusionsAccording to previous findings, metformin has been linked to lower breast cancer risk in women with type 2 diabetes. Furthermore, the findings of this study corroborate the literature on this subject by indicating that there is a substantial connection between metformin use and a lower risk of breast cancer in women with type 2 diabetes. However, further in vitro and in vivo experiments are crucial to investigate the protective effect of metformin against breast cancer and to confirm our findings.

Indexed as

breast cancerdiabetesmetformin

Identifiers

PMID36766896
PMCPMC9914021

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.