Evidence map›Paper›PMID 36766893›Full record

ArticleHealthcare (Basel, Switzerland)2023

Cancer of the Cervix in Bulgaria: Epidemiology of a Crisis.

Angel Yordanov, Mariela Vasileva-Slaveva, Noya Galai, David Faraggi, Milan Paul Kubelac, Irina Tripac-Iacovleva, Neville Calleja, Riccardo Di Fiore, Jean Calleja-Agius

Abstract read
In one paragraph

Article in Healthcare (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Angel YordanovDepartment of Gynecological Oncology, Medical Universiy Pleven, 5800 Pleven, Bulgaria.ORCID 0000-0002-7719-382X
Mariela Vasileva-SlavevaDepartment of Breast Surgery, "Dr. Shterev" Hospital, 1330 Sofia, Bulgaria.ORCID 0000-0002-6180-3742
Noya GalaiDepartment of Statistics, University of Haifa, Haifa 31905, Israel.
David FaraggiDepartment of Statistics, University of Haifa, Haifa 31905, Israel.ORCID 0000-0003-2131-620X
Milan Paul KubelacDepartment of Medical Oncology, The Oncology Institute "Prof. Dr. Ion Chiricuţă", 400015 Cluj-Napoca, Romania.ORCID 0000-0001-7957-9796
Irina Tripac-IacovlevaDepartment of Gynaecology, The Oncology Institute of Moldova, MD 2025 Chisinau, Moldova.
Neville CallejaDirectorate for Health Information and Research, PTA 1313 Tal-Pietà, Malta.
Riccardo Di FioreDepartment of Anatomy, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta.ORCID 0000-0003-4905-6948
Jean Calleja-AgiusDepartment of Anatomy, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta.ORCID 0000-0001-6369-0297

Funding

Bulgarian National Science Fund MеMoMi: Mechanisms of Modulating the immune response in the tumor and its Microenvironment for development of prognostic groups and optimizing the treatment algorithm in patients with cancer of the uterine cervixGYNOCARE-"European network for Gynaecological Rare Cancer research: From Concept to Cure" CA18117
6 · The paper itself

Abstract

Eastern Europe continues to have the highest rates of cancer of the uterine cervix (CUC) and human papillomavirus (HPV) infection in Europe.

aimThe aim of this study was to investigate CUC trends in Bulgaria in the context of a lack of a population-based screening program and a demographic crisis. METHODOLOGY: This was a retrospective study of 7861 CUC patients who were registered in the Bulgarian National Cancer Registry (BNCR) between 2013 and 2020 and followed up with until March 2022. We used descriptive statistics and modeling to assess temporal trends in new CUC incidence rates and identify factors associated with survival.

resultsBulgaria's population has decreased by 11.5% between 2011 and 2021. The CUC incidence rate decreased from 29.5/100,000 in 2013 to 23.2/100,000 in 2020 but remains very high. The proportion of patients diagnosed in earlier stages of CUC has decreased over time. Up to 19% of patients with CUC in Bulgaria are diagnosed between the age of 35 and 44 years. The median survival was 101.5 months, with some improvement in later years (adjusted HR = 0.83 for 2017-2020).

conclusionsIn countries with well-established population-based screening, CUC is nowadays considered a rare disease. However, it is not considered rare in Bulgaria. Population-based screening starting at an earlier age is the fastest way to improve outcomes.

Indexed as

cancer of the uterine cervixhuman papillomavirus (HPV)screening programssurvival

Identifiers

PMID36766893
PMCPMC9914859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.