Evidence map›Paper›PMID 36766721›Full record

ArticleCells2023

Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer's Disease Pathogenesis.

Lucia Barazzuol, Domenico Cieri, Nicola Facchinello, Tito Calì, Philip Washbourne, Francesco Argenton, Paola Pizzo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Lucia BarazzuolDepartment of Biomedical Sciences, University of Padova, 35131 Padua, Italy.
Domenico CieriDepartment of Biomedical Sciences, University of Padova, 35131 Padua, Italy.
Nicola FacchinelloDepartment of Biomedical Sciences, University of Padova, 35131 Padua, Italy.ORCID 0000-0003-4898-4064
Tito CalìDepartment of Biomedical Sciences, University of Padova, 35131 Padua, Italy.ORCID 0000-0002-8901-1659
Philip WashbourneInstitute of Neuroscience, University of Oregon, Eugene, OR 97403, USA.ORCID 0000-0003-1851-1282
Francesco ArgentonDepartment of Biology, University of Padova, 35131 Padua, Italy.ORCID 0000-0002-0803-8236
Paola PizzoDepartment of Biomedical Sciences, University of Padova, 35131 Padua, Italy.ORCID 0000-0001-6077-3265
University of Padua · ITUniversity of Oregon · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in presenilin 2 (PS2) have been causally linked to the development of inherited Alzheimer's disease (AD). Besides its role as part of the γ-secretase complex, mammalian PS2 is also involved, as an individual protein, in a growing number of cell processes, which result altered in AD. To gain more insight into PS2 (dys)functions, we have generated a

Indexed as

Alzheimer DiseaseZebrafishAmyloid Precursor Protein SecretasesAnimalsHumansMammalsPresenilin-2Zebrafish ProteinsAmyloid Precursor Protein SecretasesPresenilin-2Zebrafish ProteinsAlzheimer’s diseaseautophagyER-mitochondria contactsmitochondrial axonal transportpresenilin 2zebrafish

Identifiers

PMID36766721
PMCPMC9913325
OpenAlexW4317623229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.