Evidence map›Paper›PMID 36766690›Full record

ArticleCells2023

Human ApoE2 Endows Stronger Contractility in Rat Cardiomyocytes Enhancing Heart Function.

Yang Wu, Fujie Zhao, Venkata N Sure, Abdulgafar Ibrahim, Changjiang Yu, Sean M Carr, Ping Song

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yang WuCenter for Molecular and Translational Medicine, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0002-0772-0532
Fujie ZhaoCenter for Molecular and Translational Medicine, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0003-0997-8972
Venkata N SureCenter for Molecular and Translational Medicine, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0002-3657-962X
Abdulgafar IbrahimCenter for Molecular and Translational Medicine, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0001-7685-414X
Changjiang YuCenter for Molecular and Translational Medicine, Georgia State University, Atlanta, GA 30303, USA.
Sean M CarrCenter for Molecular and Translational Medicine, Georgia State University, Atlanta, GA 30303, USA.
Ping SongCenter for Molecular and Translational Medicine, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0002-6143-4270
Georgia State University · US

Funding

MKP1, VSMC, and Vascular RemodelingR01HL140954 · NHLBI · GEORGIA STATE UNIVERSITY · PI SONG, PING, ZOU, MING-HUI · 2018 to 2021
$2.8M
Foundation for the National Institutes of Health HL140954, HL110488NHLBI NIH HHS R01 HL140954
6 · The paper itself

Abstract

(1) Background: Apolipoprotein E (ApoE) is a critical plasma apolipoprotein for lipid transport and nonlipid-related functions. Humans possess three isoforms of ApoE (2, 3, and 4). ApoE2, which exhibits beneficial effects on cardiac health, has not been adequately studied. (2) Methods: We investigated the cardiac phenotypes of the humanized ApoE knock-in (hApoE KI) rats and compared to wild-type (WT) and ApoE knock-out (ApoE KO) rats using echocardiography, ultrasound, blood pressure measurements, histology strategies, cell culture, Seahorse XF, cardiomyocyte contractility and intracellular Ca

Indexed as

Myocytes, CardiacSarcoplasmic ReticulumAnimalsApolipoprotein E2EchocardiographyHumansRatsApolipoprotein E2contractile function of the heartfatty acid β-oxidationhuman ApoE isoformintracellular Ca2+ transientrat model

Identifiers

PMID36766690
PMCPMC9913850
OpenAlexW4316813402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.