ReviewDiagnostics (Basel, Switzerland)2023
Acquired Hemophilia A: An Update on the Etiopathogenesis, Diagnosis, and Treatment.
Review in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acquired Hemophilia A after SARS-CoV-2 Infection: A Case Report and an Updated Systematic Review.Biomedicines · 2023Pooled it
- When A Fall Isn't Just a Fall: Delayed Diagnosis of Acquired Hemophilia A in a Nonagenarian Patient.The American journal of case reports · 2026Article
- Hematoma, Hemarthrosis, and Hemotympanum: A Case Report of Acquired Hemophilia A.Journal of education & teaching in emergency medicine · 2026Article
- Acquired hemophilia A following influenza vaccination: a case report and literature review.Annals of hematology · 2026Review
- Massive Haemothorax Following CT-Guided Lung Biopsy Revealing Previously Undiagnosed Acquired Haemophilia A.Cureus · 2026Article
- Delayed diagnosis of acquired hemophilia a complicating hepatocellular carcinoma: a rare case of hepatectomy following atezolizumab and bevacizumab therapy.Clinical journal of gastroenterology · 2026Article
- Hemorrhagic Shock and Massive Abdominal Wall Hematoma After Cesarean Section in a Patient with Peripartum Acquired Hemophilia A:A Case Report.International journal of women's health · 2026Article
- A Case of Acquired Hemophilia A Following Robot-Assisted Minimally Invasive Esophagectomy.Surgical case reports · 2026Article
- Case Report: Differential diagnosis and clinical management of isolated prolonged activated partial thromboplastin time.Frontiers in immunology · 2026Article
- Evaluation of Autoimmune FVIII Inhibitor Using Clot Waveform Analysis in Emicizumab-Treated Patients.Journal of clinical medicine · 2025Article
- Long-Term Experience with Acquired Haemophilia A: A 40-Year Single-Centre Study of Clinical Features and Outcome.Journal of clinical medicine · 2025Article
- Recurrent hemoptysis after laryngectomy-acquired hemophilia induced by laryngeal cancer surgery and chemoradiotherapy: A case report.World journal of clinical cases · 2025Article
- Deep learning model for screening causes of activated partial thromboplastin time prolongation using clot waveform analysis at multiple wavelengths.Scientific reports · 2025Article
- Endovascular Embolization in Acquired Hemophilia A: A Case Study Highlighting Diagnostic and Therapeutic Strategies.The American journal of case reports · 2025Article
- Acquired Hemophilia-A Case Series and Review.Journal of clinical medicine · 2025Review
- A rare case of postoperative hemorrhage following laparoscopic cholecystectomy - A case report.Heliyon · 2025Article
- Role of the Hemostasis and Thrombosis Unit in the Management of Patients with Acquired Hemophilia ATurkish journal of haematology : official journal of Turkish Society of Haematology · 2024Article
- An Unusual Cause of Refractory Bleeding in Cirrhosis.ACG case reports journal · 2024Article
- Genetics and Epigenetics in Acquired Hemophilia A: From Bench to Bedside.Current issues in molecular biology · 2024Review
- Bleeder's Femur: The Proximal Femoral Morphology in Hemophilic Patients Who Underwent Total Hip Arthroplasty.Orthopaedic surgery · 2024Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acquired haemophilia A (AHA) is a rare bleeding disorder caused by inhibitory autoantibodies against coagulation factor VIII (FVIII). AHA is a disease that most commonly affects the elderly but has also been observed in children and in the postpartum period. AHA is idiopathic in 50% of cases and is associated with autoimmune diseases, malignancies, and infections in the remaining 50%. Recently, cases of association between AHA, COVID-19 vaccination, and infection have been reported in the literature. For diagnoses, determining FVIII levels is crucial to distinguish the different causes of aPTT prolongation. Treatment of AHA is based on bypassing agents (recombinant factor VIIa, activated prothrombin complex concentrate) and porcine FVIII to control the bleeding and immunosuppressive therapy (corticosteroids, rituximab, cyclophosphamide) to suppress autoantibody production. It is important to start a prophylactic regimen to prevent further bleeding episodes until the inhibitor is negative. Recently, the series of cases reported in the literature suggest that emicizumab may provide effective and safe haemorrhage prophylaxis in the outpatient setting.
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