Evidence map›Paper›PMID 36766497›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Longitudinal Structure-Function Evaluation in a Patient with

Andrea Cusumano, Benedetto Falsini, Fabian D'Apolito, Michele D'Ambrosio, Jacopo Sebastiani, Raffaella Cascella, Shila Barati, Emiliano Giardina

Abstract readCase Reports
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Genes · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrea CusumanoDepartment of Ophthalmology, Tor Vergata University, 00133 Rome, Italy.
Benedetto FalsiniMacula & Genoma Foundation, 00133 Rome, Italy.ORCID 0000-0002-1694-1062
Fabian D'ApolitoMacula & Genoma Foundation, 00133 Rome, Italy.
Michele D'AmbrosioMacula & Genoma Foundation, 00133 Rome, Italy.
Jacopo SebastianiMacula & Genoma Foundation, 00133 Rome, Italy.
Raffaella CascellaDepartment of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy.
Shila BaratiDepartment of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy.ORCID 0000-0002-0297-2271
Emiliano GiardinaMacula & Genoma Foundation, 00133 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRetinal dystrophies related to damaging variants in the cadherin-related family member 1 (

methodsA 14-year-old girl was evaluated between 2019 and 2022. An ophthalmological assessment, including color vision, perimetry, electroretinography, and multimodal imaging of the retina, was performed periodically every six months. Next-generation sequencing disclosed two likely pathogenic/pathogenic variants in the

resultsAt first examination, the patient showed a cone-rod pattern retinal dystrophy. Over follow-up, there was a decline of visual acuity and perimetric sensitivity (by ≥0.3 and 0.6 log units, respectively). Visual loss was associated with a progressive increase in inner retinal thickness (by 30%). Outer retina showed no detectable changes over the follow-up.

conclusionsThe results indicate that, in this patient with a

Indexed as

CDHR1 genecone–rod dystrophyinner retinaretinal remodelingretinal structurevisual function

Identifiers

PMID36766497
PMCPMC9914892

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.