Evidence map›Paper›PMID 36766478›Full record

ArticleDiagnostics (Basel, Switzerland)2023

First Molecular Characterization of Chronic Hepatitis B Carriers in Timbuktu, Mali.

Philip Lawrence, Mawlouda Chabane, Lucie Abrouk, Adrien Thiesson, Diakaridia Berthé, Amadou B Diarra, Karim Bengaly, Brehima Traoré, Djibril Kassogué, Geoffroy Durand and 6 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Philip LawrenceCONFLUENCE: Sciences et Humanités Confluence (EA 1598), Université Catholique de Lyon (UCLy), 69002 Lyon, France.
Mawlouda ChabaneCentre d'Infectiologie Charles Mérieux, Bamako BPE2283, Mali.
Lucie AbroukCONFLUENCE: Sciences et Humanités Confluence (EA 1598), Université Catholique de Lyon (UCLy), 69002 Lyon, France.
Adrien ThiessonCONFLUENCE: Sciences et Humanités Confluence (EA 1598), Université Catholique de Lyon (UCLy), 69002 Lyon, France.
Diakaridia BerthéHôpital Régional de Tombouctou, Timbuktu, Mali.
Amadou B DiarraCentre National de Transfusion Sanguine (CNTS, National Blood Bank), Bamako BPE1520, Mali.
Karim BengalyCentre d'Infectiologie Charles Mérieux, Bamako BPE2283, Mali.
Brehima TraoréCentre d'Infectiologie Charles Mérieux, Bamako BPE2283, Mali.ORCID 0000-0001-9075-9157
Djibril KassoguéHôpital Régional de Tombouctou, Timbuktu, Mali.
Geoffroy DurandInternational Agency for Research on Cancer, 69008 Lyon, France.
Catherine VoegeleInternational Agency for Research on Cancer, 69008 Lyon, France.
Florence Le Calvez-KelmInternational Agency for Research on Cancer, 69008 Lyon, France.
Nicolas SteenkesteFondation Mérieux, 69002 Lyon, France.
Pierre HainautInstitute of Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, 38700 La Tronche, France.
Bourema KouribaCentre d'Infectiologie Charles Mérieux, Bamako BPE2283, Mali.ORCID 0000-0002-3419-5972
Emmanuelle GormallyCONFLUENCE: Sciences et Humanités Confluence (EA 1598), Université Catholique de Lyon (UCLy), 69002 Lyon, France.
Université catholique de lyon · FRCentre international de recherche sur le cancer · FRCentre National de la Recherche Scientifique · FRCentre Pour le Développement des Vaccins-Mali · MLFondation Mérieux · FR

Funding

World Health Organization 001
6 · The paper itself

Abstract

In Mali, hepatocellular carcinoma (HCC) is the third and sixth most common cancer in men and women, respectively. Mali comprises several distinct climato-ecological zones. Most studies to date have been conducted in the sub-Sahelian zone of southern Mali, including the capital city Bamako. In this part of the country, the main risk factors for HCC are chronic hepatitis B virus (HBV) carriage and dietary exposure to aflatoxins, a well-known hepatocarcinogen. Data are scarce for other ecological zones, but our preliminary data from 721 blood donors in the area of Timbuktu, presented in this study, suggest that chronic HBV carriage is also endemic in the northern Saharan zone of Mali. For further study, 29 healthy HBV chronic carrier volunteers were recruited from the blood transfusion center in Timbuktu. Successful viral genotyping in 20 volunteers revealed HBV genotype E in 13 cases and D in 7 cases, suggesting that this geographical and anthropological transition zone may also represent a transition zone between HBV genotypes that dominate sub-Saharan and northern Africa, respectively. Sequencing of circulating cell-free plasma DNA (cfDNA) from donors did not reveal the presence of the

Indexed as

aflatoxinHBV Genotype EHBV HBxhepatitis B virushepatocellular carcinomaMaliTimbuktuTP53 R249S

Identifiers

PMID36766478
PMCPMC9913942
OpenAlexW4317503105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.