ArticleDiagnostics (Basel, Switzerland)2023
Identification of Key Volatile Organic Compounds Released by Gastric Tissues as Potential Non-Invasive Biomarkers for Gastric Cancer.
Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring Components, Sensors, and Techniques for Cancer Detection via eNose Technology: A Systematic Review.Sensors (Basel, Switzerland) · 2024Pooled it
- HS-GC/MS-Based Targeted Blood VOC Panel for Canine Cancer Screening Using an Integrated Classification Framework in Retrospective Korea and Thailand Cohorts.International journal of molecular sciences · 2026Article
- In Situ Growth of Lanthanide Coordination Polymers on Oxide Glass and Optical Fibers: A Promising Material for Chemical Sensing.ACS applied materials & interfaces · 2025Article
- Molecular Mechanisms ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Efficient detection of gastric cancer biomarkers on functionalized carbon nanoribbons using DFT analysis.Scientific reports · 2025Article
- Progress and challenges of developing volatile metabolites from exhaled breath as a biomarker platform.Metabolomics : Official journal of the Metabolomic Society · 2024Review
- Advancements in breath-based diagnostics for pancreatic cancer: Current insights and future perspectives.World journal of gastrointestinal oncology · 2024Article
- Volatile organic compounds for the detection of hepatocellular carcinoma-A scoping review.iLIVER · 2024Review
- Breath Fingerprint of Colorectal Cancer Patients Based on the Gas Chromatography-Mass Spectrometry Analysis.International journal of molecular sciences · 2024Article
- Identification of Volatile Markers of Colorectal Cancer from Tumor Tissues Using Volatilomic Approach.Molecules (Basel, Switzerland) · 2023Article
- Volatile Markers for Cancer in Exhaled Breath-Could They Be the Signature of the Gut Microbiota?Molecules (Basel, Switzerland) · 2023Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundVolatilomics is a powerful tool capable of providing novel biomarkers for medical diagnosis and therapy monitoring. The objective of this study is to identify potential volatile biomarkers of gastric cancer.
methodsThe volatilomic signatures of gastric tissues obtained from two distinct populations were investigated using gas chromatography with mass spectrometric detection.
resultsAmongst the volatiles emitted, nineteen showed differences in their headspace concentrations above the normal and cancer tissues in at least one population of patients. Headspace levels of seven compounds (hexanal, nonanal, cyclohexanone, 2-nonanone, pyrrole, pyridine, and phenol) were significantly higher above the cancer tissue, whereas eleven volatiles (ethyl acetate, acetoin, 2,3-butanedione, 3-methyl-1-butanol, 2-pentanone, γ-butyrolactone, DL-limonene, benzaldehyde, 2-methyl-1-propanol, benzonitrile, and 3-methyl-butanal) were higher above the non-cancerous tissue. One compound, isoprene, exhibited contradictory alterations in both cohorts. Five compounds, pyridine, ethyl acetate, acetoin, 2,3-butanedione, and 3-methyl-1-butanol, showed consistent cancer-related changes in both populations.
conclusionsPyridine is found to be the most promising biomarker candidate for detecting gastric cancer. The difference in the volatilomic signatures can be explained by cancer-related changes in the activity of certain enzymes, or pathways. The results of this study confirm that the chemical fingerprint formed by volatiles in gastric tissue is altered by gastric cancer.
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