ArticleAnimals : an open access journal from MDPI2023
Reference Intervals and Percentiles for Hematologic and Serum Biochemical Values in Captive Bred Rhesus (
Article in Animals : an open access journal from MDPI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Evaluation of lipid nanoparticle adjuvants with different PEG lipid ratios and phospholipid modifications in non-human primates.Molecular therapy. Nucleic acids · 2026Article
- The social circumstances of the maternal experience and its biobehavioral associations, in rhesus macaques (Macaca mulatta).Animal reproduction science · 2026Article
- AAV-based gene therapy with modified HEXB confers lasting therapeutic benefits in GM2 gangliosidosis models.Cell reports. Medicine · 2026Article
- Hemolysis-induced hepatic ferroptosis following xenotransfusion of genetically modified pig red blood cells.Scientific reports · 2025Article
- 13-Month Follow Up of Acclimation of Cynomolgus Macaques (Macaca fascicularis) on Haematology, Serum Biochemistry, and Body Weight Changes.Journal of medical primatology · 2025Article
- Reference intervals for hematologic and biochemical values in Cynomolgus monkeys from different breeding populations in China.Experimental animals · 2025Article
- Biochemical and hematological reference intervals in rhesus and cynomolgus macaques and implications for vaccine and drug development.Lab animal · 2025Article
- Hematological and Serum Biochemical Reference Intervals for Alphaxalone Sedated Common Marmosets (Animals : an open access journal from MDPI · 2024Article
- Long-acting reversible contraception with etonogestrel implants in female macaques (Frontiers in veterinary science · 2023Article
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Authors and funding
7 authors.
Funding
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Abstract
Several physiological characteristics and housing conditions are known to affect hematologic and serum biochemical values in macaques. However, the studies that have been conducted either report values calculated based on a small number of animals, were designed specifically to document the effect of a particular condition on the normal range of hematologic and serum biochemical values, or used parametric assumptions to calculate hematologic and serum biochemical reference intervals. We conducted a retrospective longitudinal cohort study to estimate reference intervals for hematologic and serum biochemical values in clinically healthy macaques based on observed percentiles without parametric assumptions. Data were obtained as part of the Biomedical Primate Research Centre (Rijswijk, The Netherlands) health monitoring program between 2018 and 2021. In total, 4009 blood samples from 1475 macaques were analyzed with a maximum of one repeat per year per animal. Data were established by species, gender, age, weight-for-height indices, pregnancy, sedation protocol, and housing conditions. Most of the parameters profoundly affected just some hematologic and serum biochemical values. A significant glucose difference was observed between the ketamine and ketamine-medetomidine sedation protocols. The results emphasize the importance of establishing uniform experimental groups with validated animal husbandry and housing conditions to improve the reproducibility of the experiments.
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