Evidence map›Paper›PMID 36766246›Full record

ArticleAnimals : an open access journal from MDPI2023

Retrospective Study of T Cell Leukaemia (Large Granular Lymphocyte Variant) in Dogs Associated with Suspected Immune-Mediated Cytopaenia(s) in the Absence of Peripheral Lymphocytosis.

Angelo Capasso, Elizabeth Villers, James Elliott, Nic Ilchyshyn, Ian Hopkins, Ferran Valls Sanchez, Sara Verganti

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Angelo CapassoDepartment of Oncology, Dick White Referrals, Station Farm, London Road, Six Mile Bottom CB8 0UH, UK.ORCID 0000-0001-6061-2162
Elizabeth VillersDepartment of Pathology, Dick White Referrals, Station Farm, London Road, Six Mile Bottom CB8 0UH, UK.
James ElliottDepartment of Oncology, Southfields, Cranes Point, Gardiners Ln S, Basildon SS14 3AP, UK.
Nic IlchyshynDepartment of Pathology, Dick White Referrals, Station Farm, London Road, Six Mile Bottom CB8 0UH, UK.
Ian HopkinsOackwood Veterinary Referrals, Willows Veterinary Hospital, Chester Road, Hartford, Nortwich CW8 1LP, UK.
Ferran Valls SanchezDepartment of Internal Medicine, Dick White Referrals, Station Farm, London Road, Six Mile Bottom CB8 0UH, UK.
Sara VergantiDepartment of Oncology, Dick White Referrals, Station Farm, London Road, Six Mile Bottom CB8 0UH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Canine chronic large granular lymphocyte (LGL) leukaemia is commonly characterised by moderate to marked lymphocytosis but not neutropaenia. In humans, LGL leukaemia is often associated with autoimmune disorders, including immune-mediated cytopaenias (mainly neutropaenia). This presentation is rare in dogs. The aim of this retrospective study was to describe the clinical characteristics, treatments, and outcomes of dogs with chronic LGL leukaemia with suspected immune-mediated cytopaenia. Six dogs with a median age of 4.5 years (range 2-8 years) were included in the study. The most common presenting signs were pyrexia and lethargy. All dogs had severe neutropaenia (median neutrophil count 0.07 × 10

Indexed as

bone marrowchemotherapychronic lymphocytic leukaemiacytopaeniasdogimmune-mediated neutropaenialarge granular lymphocyte leukaemiaT cell leukaemia

Identifiers

PMID36766246
PMCPMC9913808

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.