Evidence map›Paper›PMID 36765927›Full record

ArticleCancers2023

Utility of Comprehensive Genomic Profiling Tests for Patients with Incurable Pancreatic Cancer in Clinical Practice.

Takuo Yamai, Kenji Ikezawa, Naotoshi Sugimoto, Makiko Urabe, Yugo Kai, Ryoji Takada, Tasuku Nakabori, Hiroyuki Uehara, Takahisa Kawamura, Kei Kunimasa and 10 more

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Takuo YamaiDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.ORCID 0000-0002-5448-4763
Kenji IkezawaDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.ORCID 0000-0001-7517-8960
Naotoshi SugimotoDepartment of Genetic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Makiko UrabeDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Yugo KaiDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Ryoji TakadaDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.ORCID 0000-0002-6568-8091
Tasuku NakaboriDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Hiroyuki UeharaDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Takahisa KawamuraDepartment of Thoracic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Kei KunimasaDepartment of Thoracic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Sachiko YamamotoDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Toru WakamatsuMusculoskeletal Oncology Service, Osaka International Cancer Institute, Osaka 541-8567, Japan.ORCID 0000-0002-3073-0595
Takuji HayashiDepartment of Urology, Osaka International Cancer Institute, Osaka 541-8567, Japan.ORCID 0000-0003-2030-3087
Yoji KukitaLaboratory of Genomic Pathology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Fumie FujisawaDepartment of Genetic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.ORCID 0000-0001-8436-9072
Tazuko InoueDepartment of Genetic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Yuko YamaguchiDepartment of Genetic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Tomoyuki YamasakiDepartment of Endocrinology/Metabolism Internal Medicine, Clinical Examination, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Keiichiro HonmaDepartment of Diagnostic Pathology and Cytology, Osaka International Cancer Institute, Osaka 541-8567, Japan.ORCID 0000-0001-5193-5891
Kazuyoshi OhkawaDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although comprehensive genomic profiling (CGP) tests have been covered under the Japanese national health insurance program since 2018, the utility and issues of CGP tests have not been clarified. We retrospectively reviewed 115 patients with incurable pancreatic cancer (IPC) who underwent CGP tests in a Japanese cancer referral center from November 2019 to August 2021. We evaluated the results of CGP tests, treatments based on CGP tests, and survival time. Eight cases (6.9%) were diagnosed as tumor mutation burden-high (TMB-H) and/or microsatellite instability-high (MSI-H). The gene mutation rates of

Indexed as

comprehensive genomic profiling testshomologous recombination deficiencypancreatic cancer

Identifiers

PMID36765927
PMCPMC9913675

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.