Evidence map›Paper›PMID 36765865›Full record

ArticleCancers2023

Patterns of Somatic Variants in Colorectal Adenoma and Carcinoma Tissue and Matched Plasma Samples from the Hungarian Oncogenome Program.

Alexandra Kalmár, Orsolya Galamb, Gitta Szabó, Orsolya Pipek, Anna Medgyes-Horváth, Barbara K Barták, Zsófia B Nagy, Krisztina A Szigeti, Sára Zsigrai, István Csabai and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexandra KalmárDepartment of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.
Orsolya GalambMTA-SE Molecular Medicine Research Group, Eötvös Loránd Research Network, 1083 Budapest, Hungary.
Gitta SzabóDepartment of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.
Orsolya PipekDepartment of Physics of Complex Systems, ELTE Eötvös Loránd University, 1117 Budapest, Hungary.ORCID 0000-0001-8109-0340
Anna Medgyes-HorváthDepartment of Physics of Complex Systems, ELTE Eötvös Loránd University, 1117 Budapest, Hungary.ORCID 0000-0003-4435-5797
Barbara K BartákDepartment of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.
Zsófia B NagyDepartment of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.
Krisztina A SzigetiDepartment of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.
Sára ZsigraiDepartment of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.
István CsabaiDepartment of Physics of Complex Systems, ELTE Eötvös Loránd University, 1117 Budapest, Hungary.
Péter IgazDepartment of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.ORCID 0000-0003-2192-554X
Béla MolnárDepartment of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.
István TakácsDepartment of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.

Funding

HUNGARIAN NATIONAL OFFICE FOR RESEARCH AND TECHNOLOGY FIEK_16-1-2016-0005HUNGARIAN NATIONAL OFFICE FOR RESEARCH AND TECHNOLOGY NKVP_16-1-2016-0004HUNGARIAN NATIONAL OFFICE FOR RESEARCH AND TECHNOLOGY PIACI-KFI-2021-000298National Research, Development and Innovation Fund by the Ministry of Innovation and Technology of Hungary TKP2021-EGA-24
6 · The paper itself

Abstract

Analysis of circulating cell-free DNA (cfDNA) of colorectal adenoma (AD) and cancer (CRC) patients provides a minimally invasive approach that is able to explore genetic alterations. It is unknown whether there are specific genetic variants that could explain the high prevalence of CRC in Hungary. Whole-exome sequencing (WES) was performed on colon tissues (27 AD, 51 CRC) and matched cfDNAs (17 AD, 33 CRC); furthermore, targeted panel sequencing was performed on a subset of cfDNA samples. The most frequently mutated genes were

Indexed as

colorectal adenomacolorectal carcinomaCRCliquid biopsytissue biopsywhole-exome sequencing

Identifiers

PMID36765865
PMCPMC9913259

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.