Evidence map›Paper›PMID 36765803›Full record

ArticleCancers2023

Extradural Primary Malignant Spinal Tumors in a Population Younger than 25 Years: An Ambispective International Multicenter Study on Onco-Surgical Outcomes.

Alexander C Disch, Stefano Boriani, Alessandro Luzzati, Laurence D Rhines, Charles G Fisher, Aron Lazary, Ziya L Gokaslan, Dean Chou, Michelle J Clarke, Michael G Fehlings and 4 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01643174 (Predictors of Mortality and Morbidity in the Surgical Management of Primary Tumors of the Spine), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01643174 completednot on this map

Predictors of Mortality and Morbidity in the Surgical Management of Primary Tumors of the Spine: A Multi-center Retrospective Cohort Study With a Cross-Sectional Survival Check

TypeobservationalSponsorAO Foundation, AO SpineRan2012 to 2013Enrolled1,600ConditionsSpine Tumor
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alexander C DischUniversity Center for Orthopedics, Trauma & Plastic Surgery, University Comprehensive Spine Center (UCSC), University Hospital Carl Gustav Carus Dresden at the TU Dresden, 01307 Dresden, Germany.
Stefano BorianiI.R.C.C.S. Istituto Ortopedico Galeazzi, 20161 Milan, Italy.
Alessandro LuzzatiI.R.C.C.S. Istituto Ortopedico Galeazzi, 20161 Milan, Italy.
Laurence D RhinesDepartment of Neurosurgery, MD Anderson Cancer Center, Houston, TX 77030, USA.
Charles G FisherDepartment of Orthopaedics, Faculty of Medicine, The University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Aron LazaryNational Center for Spinal Disorders, 1126 Budapest, Hungary.
Ziya L GokaslanDepartment of Neurosurgery, The Warren Alpert Medical School of Brown University, Rhode Island Hospital and The Miriam Hospital, Providence, RI 02903, USA.
Dean ChouDepartment of Neurosurgery, The UCSF Spine Center, University of California, San Francisco, CA 94143, USA.
Michelle J ClarkeDepartment of Neurosurgery, Mayo Clinic, Rochester, MN 55902, USA.
Michael G FehlingsDepartment of Surgery Halbert Chair, Spinal Program University of Toronto, Toronto Western Hospital University Health Network, Toronto, ON M5T 2S8, Canada.ORCID 0000-0002-5722-6364
Klaus-Dieter SchaserUniversity Center for Orthopedics, Trauma & Plastic Surgery, University Comprehensive Spine Center (UCSC), University Hospital Carl Gustav Carus Dresden at the TU Dresden, 01307 Dresden, Germany.
Nicole M GermscheidAO Spine Knowledge Forum Tumor, AO Spine, 7270 Davos, Switzerland.
Jeremy J ReynoldsOxford Spinal Surgery Unit, Oxford University Hospitals, Oxford OX3 7LE, UK.
The Ao Spine Knowledge Forum TumorAO Spine Knowledge Forum Tumor, AO Spine, 7270 Davos, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extradural malignant primary spinal tumors are rare and outcome data, especially for younger patients, is limited. In a worldwide (11 centers) study (Predictors of Mortality and Morbidity in the Surgical Management of Primary Tumors of the Spine study; ClinicalTrials.gov Identifier NCT01643174) by the AO Spine Knowledge Forum Tumor, patients surgically treated for primary tumors of the spine between 1992 and 2012, were retrospectively analyzed from a prospective database of their medical history. Medical history, tumor characteristics, diagnostics, treatments, cross-sectional survival, and local recurrences were analyzed. Sixty-eight cases (32 f; 36 m), at an average age of 18.6 ± 4.7 years at the time of diagnosis, were identified (median follow-up 2.9 years). The most common entities were Ewing's sarcoma (42.6%). Of the patients, 28% had undergone previous spine tumor surgery in another center (84% with intralesional margins). Resection was considered "Enneking appropriate" (EA) in 47.8% of the cases. Of the patients, 77.9% underwent chemotherapy and 50% radiotherapy. A local recurrence occurred in 36.4%. Over a third of patients died within a 10-year follow-up period. Kaplan-Meier-analysis demonstrated statistically significant overall survival (

Indexed as

adolescentaggressive resectionchildrenextradural malignant primary tumorspinal tumorsurgical outcome

Identifiers

PMID36765803
PMCPMC9913243

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.