Evidence map›Paper›PMID 36765618›Full record

ArticleCancers2023

Changes in Nucleolin Expression during Malignant Transformation Leading to Ovarian High-Grade Serous Carcinoma.

Elizabeth A Paris, Janice M Bahr, Sanjib Basu, Animesh Barua

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Elizabeth A ParisDepartment of Anatomy & Cell Biology, Rush University Medical Center, Chicago, IL 60612, USA.ORCID 0000-0002-7594-2954
Janice M BahrDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Sanjib BasuDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Animesh BaruaDepartment of Anatomy & Cell Biology, Rush University Medical Center, Chicago, IL 60612, USA.
Rush University Medical Center · USUniversity of Illinois Urbana-Champaign · US

Funding

Early detection of ovarian cancer by serum marker and targeted ultrasound imagingR01CA210370 · NCI · RUSH UNIVERSITY MEDICAL CENTER · PI BARUA, ANIMESH · 2016 to 2019
$1.4M
National Institutes of Health R01 CA210370NCI NIH HHS R01 CA210370
6 · The paper itself

Abstract

objectiveOvarian high-grade serous carcinoma (HGSC) is a fatal malignancy of women. Alterations in the expression of nuclear proteins are early steps in malignant transformation; nucleolin is one such protein. Changes in nucleolin expression and circulatory levels during ovarian HGSC development are unknown. The study goal was to determine if tissue and circulatory levels of nucleolin change in response to malignant transformation leading to ovarian HGSC.

methodsSera, ovaries, and BRCA+ fimbria from healthy subjects, and sera and tumor tissues from patients (

resultsCompared with normal, nucleolin expression was higher in patients and hens with ovarian HGSC and in women with a risk of HGSC (

conclusionThis pilot study concluded that tissue and serum levels of nucleolin increase in association with malignant changes in ovaries and fimbriae leading to ovarian HGSC.

Indexed as

chicken modelearly detectionfimbrianucleolinovarian cancerserum markerultrasound imaging

Identifiers

PMID36765618
PMCPMC9913361
OpenAlexW4317738079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.