Evidence map›Paper›PMID 36765600›Full record

ArticleCancers2023

Bevacizumab versus Ramucirumab in EGFR-Mutated Metastatic Non-Small-Cell Lung Cancer Patients: A Real-World Observational Study.

Wen-Chien Cheng, Yi-Cheng Shen, Chieh-Lung Chen, Wei-Chih Liao, Chia-Hung Chen, Hung-Jen Chen, Chih-Yen Tu, Te-Chun Hsia

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wen-Chien ChengDepartment of Internal Medicine, Division of Pulmonary and Critical Care, China Medical University Hospital, Taichung 404327, Taiwan.ORCID 0000-0001-8628-6000
Yi-Cheng ShenDepartment of Internal Medicine, Division of Pulmonary and Critical Care, China Medical University Hospital, Taichung 404327, Taiwan.ORCID 0000-0001-5459-5378
Chieh-Lung ChenDepartment of Internal Medicine, Division of Pulmonary and Critical Care, China Medical University Hospital, Taichung 404327, Taiwan.
Wei-Chih LiaoDepartment of Internal Medicine, Division of Pulmonary and Critical Care, China Medical University Hospital, Taichung 404327, Taiwan.
Chia-Hung ChenDepartment of Internal Medicine, Division of Pulmonary and Critical Care, China Medical University Hospital, Taichung 404327, Taiwan.ORCID 0000-0003-1158-9722
Hung-Jen ChenDepartment of Internal Medicine, Division of Pulmonary and Critical Care, China Medical University Hospital, Taichung 404327, Taiwan.ORCID 0000-0001-6000-9021
Chih-Yen TuDepartment of Internal Medicine, Division of Pulmonary and Critical Care, China Medical University Hospital, Taichung 404327, Taiwan.
Te-Chun HsiaDepartment of Internal Medicine, Division of Pulmonary and Critical Care, China Medical University Hospital, Taichung 404327, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The combination of bevacizumab or ramucirumab with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy, chemotherapy, or immunotherapy for non-small-cell lung cancer (NSCLC) patients with EGFR mutations could have survival benefits. However, no study, to date, has been conducted to compare the efficacy and safety of these two antiangiogenic therapies (AATs). Stage IIIB to IV EGFR-mutated NSCLC patients who received first-line EGFR-TKIs between January 2014 and May 2022 were enrolled. These patients were divided into two groups: those receiving bevacizumab and those receiving ramucirumab as a combination therapy in any line of treatment. Ninety-six patients were enrolled in this study's final analysis. The progression-free survival (PFS) of patients who received front-line AATs combined with EGFR-TKI therapy was longer than that of patients receiving later-line AATs combined with other therapies (19.6 vs. 10.0 months,

Indexed as

anti-angiogenesis therapyEGFRepidermal growth factor receptornon-small cell lung cancerNSCLC

Identifiers

PMID36765600
PMCPMC9913875

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.