Evidence map›Paper›PMID 36765546›Full record

ArticleCancers2023

Efficacy of Organ Preservation Strategy by Adjuvant Chemoradiotherapy after Non-Curative Endoscopic Resection for Superficial SCC: A Multicenter Western Study.

Arthur Berger, Guillaume Perrod, Mathieu Pioche, Maximilien Barret, Elodie Cesbron-Métivier, Vincent Lépilliez, Marianne Hupé, Enrique Perez-Cuadrado-Robles, Franck Cholet, Augustin Daubigny and 9 more

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Arthur BergerCHU Bordeaux, Department of Gastroenterology and Digestive Endoscopy, Univ. Bordeaux, 33000 Bordeaux, France.ORCID 0000-0003-0387-4734
Guillaume PerrodDepartment of Gastroenterology and Digestive Endoscopy, Georges Pompidou European Hospital, Paris-Cité University, 75015 Paris, France.
Mathieu PiocheDepartment of Hepatology and Gastroenterology, Edouard Herriot Hospital, Lyon 1 University Claude Bernard, 69003 Lyon, France.
Maximilien BarretDepartment of Gastroenterology and Digestive Endoscopy, Cochin University Hospital, University of Paris, 75014 Paris, France.ORCID 0000-0002-0566-7870
Elodie Cesbron-MétivierDepartment of Hepatology and Gastroenterology, Angers Teaching Hospital, Angers University, 49000 Angers, France.
Vincent LépilliezDepartment of Hepatogastroenterology, Jean Mermoz Private Hospital, Ramsay Santé, 69008 Lyon, France.ORCID 0000-0003-4868-7924
Marianne HupéCHU Bordeaux, Department of Gastroenterology and Digestive Endoscopy, Univ. Bordeaux, 33000 Bordeaux, France.
Enrique Perez-Cuadrado-RoblesDepartment of Gastroenterology and Digestive Endoscopy, Georges Pompidou European Hospital, Paris-Cité University, 75015 Paris, France.ORCID 0000-0001-8254-7453
Franck CholetDepartment of Hepatology and Gastroenterology, Brest Teaching Hospital, Brest University, 29200 Brest, France.
Augustin DaubignyDepartment of Hepatology and Gastroenterology, Brest Teaching Hospital, Brest University, 29200 Brest, France.
Charles TexierDepartment of Hepatology and Gastroenterology, Angers Teaching Hospital, Angers University, 49000 Angers, France.
Einas Abou AliDepartment of Gastroenterology and Digestive Endoscopy, Cochin University Hospital, University of Paris, 75014 Paris, France.
Edouard ChabrunCHU Bordeaux, Department of Gastroenterology and Digestive Endoscopy, Univ. Bordeaux, 33000 Bordeaux, France.
Jérémie JacquesDepartment of Hepatology and Gastroenterology, Limoges Teaching Hospital, Limoges University, 87000 Limoges, France.
Timothee WallenhorstDepartment of Hepatology and Gastroenterology, Rennes Teaching Hospital, Rennes University, 35033 Rennes, France.
Jean Baptiste ChevauxDepartment of Endoscopy and Hepatogastroenterology, Nancy Teaching Hospital, Nancy University, 54000 Nancy, France.
Marion SchaeferDepartment of Endoscopy and Hepatogastroenterology, Nancy Teaching Hospital, Nancy University, 54000 Nancy, France.ORCID 0000-0002-5002-0486
Christophe CellierDepartment of Gastroenterology and Digestive Endoscopy, Georges Pompidou European Hospital, Paris-Cité University, 75015 Paris, France.
Gabriel RahmiDepartment of Gastroenterology and Digestive Endoscopy, Georges Pompidou European Hospital, Paris-Cité University, 75015 Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn case of high risk of lymph node invasion after endoscopic resection (ER) of superficial esophageal squamous cell carcinoma (SCC), adjuvant chemoradiotherapy (CRT) can be an alternative to surgery. We assessed long-term clinical outcomes of adjuvant therapy by CRT after non-curative ER for superficial SCC.

methodsWe performed a retrospective multicenter study. From April 1999 to April 2018, all consecutive patients who underwent ER for SCC with tumor infiltration beyond the muscularis mucosae were included.

resultsA total of 137 ER were analyzed. The overall nodal or metastatic recurrence-free survival rate at 5 years was 88% and specific recurrence-free survival rates at 5 years with and without adjuvant therapy were, respectively, 97.9% and 79.1% (

conclusionIn this study, adjuvant therapy is associated with a higher recurrence-free survival rate at 5 years after non-curative ER. This result suggests this approach may be considered as an alternative to surgery in selected patients.

Indexed as

adjuvant chemoradiotherapyendoscopic resectionesophageal squamous cell carcinomaorgan preservation

Identifiers

PMID36765546
PMCPMC9913357

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.