Evidence map›Paper›PMID 36765543›Full record

ReviewCancers2023

The Current Status of Photodynamic Therapy in Cancer Treatment.

Wenqi Jiang, Mingkang Liang, Qifang Lei, Guangzhi Li, Song Wu

Abstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 1 synthesis or guideline pooled it.

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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenqi JiangThe Affiliated Luohu Hospital of Shenzhen University, School of Basic Medical Science, Health Science Center, Shenzhen University, Shenzhen 518000, China.
Mingkang LiangThe Affiliated Luohu Hospital of Shenzhen University, School of Basic Medical Science, Health Science Center, Shenzhen University, Shenzhen 518000, China.
Qifang LeiDepartment of Urology, South China Hospital, Health Science Center, Shenzhen University, Shenzhen 518116, China.
Guangzhi LiThe Affiliated Luohu Hospital of Shenzhen University, School of Basic Medical Science, Health Science Center, Shenzhen University, Shenzhen 518000, China.
Song WuThe Affiliated Luohu Hospital of Shenzhen University, School of Basic Medical Science, Health Science Center, Shenzhen University, Shenzhen 518000, China.

Funding

Guangdong Basic and Applied Basic Research Foundation 2021A1515110402Medical Scientific Research Foundation of Guangdong Province A2022024National Natural Science Foundation of Shenzhen JCYJ20210324142413034Shenzhen Scientific and technological Research Program JSGG20201103153801005
6 · The paper itself

Abstract

Although we have made great strides in treating deadly diseases over the years, cancer therapy still remains a daunting challenge. Among numerous anticancer methods, photodynamic therapy (PDT), a non-invasive therapeutic approach, has attracted much attention. PDT exhibits outstanding performance in cancer therapy, but some unavoidable disadvantages, including limited light penetration depth, poor tumor selectivity, as well as oxygen dependence, largely limit its therapeutic efficiency for solid tumors treatment. Thus, numerous strategies have gone into overcoming these obstacles, such as exploring new photosensitizers with higher photodynamic conversion efficiency, alleviating tumor hypoxia to fuel the generation of reactive oxygen species (ROS), designing tumor-targeted PS, and applying PDT-based combination strategies. In this review, we briefly summarized the PDT related tumor therapeutic approaches, which are mainly characterized by advanced PSs, these PSs have excellent conversion efficiency and additional refreshing features. We also briefly summarize PDT-based combination therapies with excellent therapeutic effects.

Indexed as

PDTPDT-based combination therapyphotosensitizer

Identifiers

PMID36765543
PMCPMC9913255

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.