Evidence map›Paper›PMID 36765391›Full record

ArticleArthritis research & therapy2023

Interferon and interferon-induced cytokines as markers of impending clinical progression in ANA

Sonya T Kim, Carolina Muñoz-Grajales, Shannon E Dunn, Raphael Schneider, Sindhu R Johnson, Zahi Touma, Zareen Ahmad, Dennisse Bonilla, Eshetu G Atenafu, Linda T Hiraki and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Sonya T KimSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada.
Carolina Muñoz-GrajalesSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada.
Shannon E DunnDepartment of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Raphael SchneiderKeenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.
Sindhu R JohnsonDepartment of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Zahi ToumaDepartment of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Zareen AhmadDepartment of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Dennisse BonillaSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada.
Eshetu G AtenafuBiostatistics Department, Princess Margaret Cancer Center, University Health Network, Toronto, Canada.
Linda T HirakiDivision of Rheumatology, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto, Toronto, ON, Canada.
Arthur BookmanDepartment of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Joan WitherSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada. joan.wither@uhnresearch.ca.
University of Toronto · CAUniversity Health Network · CAHospital for Sick Children · CAKrembil Research InstitutePrincess Margaret Cancer Centre · CASt. Michael's Hospital · CA

Funding

CIHR FRN 159563
6 · The paper itself

Abstract

backgroundElevated levels of interferons (IFNs) are a characteristic feature of systemic autoimmune rheumatic diseases (SARDs) and may be useful in predicting impending symptomatic progression in anti-nuclear antibody-positive (ANA

methodsA total of 280 subjects were studied, including 50 ANA

resultsMeasurement of IFN-α levels by high-sensitivity ELISA or Simoa correlated much better with IFN-induced gene expression than measurement of CXCL-10 or Galectin-9 levels. Despite this, high CXCL-10 and Galectin-9 levels were better predictors of subsequent progression in ANA

conclusionEasily performed ELISA assays for CXCL-10 and IFN-α can be used to predict ANA

Indexed as

Autoimmune DiseasesRheumatic DiseasesAntibodies, AntinuclearCytokinesDisease ProgressionHumansInterferon-alphaAntibodies, AntinuclearCytokinesInterferon-alphaCytokinesInterferonPre-clinicalSystemic autoimmune rheumatic diseases

Identifiers

PMID36765391
PMCPMC9912609
OpenAlexW4319983800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.