Evidence map›Paper›PMID 36765336›Full record

ArticleBMC cancer2023

Association between diverticular disease and colorectal cancer: a bidirectional mendelian randomization study.

Yanxi Zhang, Han Zhang, Jinghan Zhu, Yazhou He, Peng Wang, Doudou Li, Xiaozhuan Liu, Wen Jin, Junxi Zhang, Chuan Xu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Sex-Specific Multimorbidity-Multibehaviour Patterns in Primary Care Populations.International journal of environmental research and public health · 2025
    Observational
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Yanxi Zhang *The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Han Zhang *College of Public Health, Zhengzhou University, 450001, Zhengzhou, Henan, China.
Jinghan Zhu *The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Yazhou HeDepartment of oncology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Peng WangCollege of Public Health, Zhengzhou University, 450001, Zhengzhou, Henan, China.
Doudou LiCollege of Public Health, Zhengzhou University, 450001, Zhengzhou, Henan, China.
Xiaozhuan LiuHenan Provincial People's Hospital, Zhengzhou University, Zhengzhou, China.
Wen JinThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Junxi ZhangNHC Key Laboratory of Birth Defects Prevention & Henan Key Laboratory of Population Defects Prevention, Zhengzhou, China.
Chuan XuDepartment of Oncology, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Sciences, University of Electronic Science and Technology of China, Chengdu, China.
Zengli YuCollege of Public Health, Zhengzhou University, 450001, Zhengzhou, Henan, China.
Xin ZhaoThe Third Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Lingling CuiCollege of Public Health, Zhengzhou University, 450001, Zhengzhou, Henan, China. cuilingling0613@163.com.
Zhengzhou University · CNFirst Affiliated Hospital Zhejiang University · CNHenan Provincial People's Hospital · CNSichuan University · CNSouthern Medical University · CNThird Affiliated Hospital of Zhengzhou University · CNUniversity of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiverticular disease has been inconsistently associated with colorectal cancer risk. We conducted a bidirectional Mendelian randomization study to assess this association.

methodsForty-three and seventy single-nucleotide polymorphisms associated with diverticular disease and colorectal cancer at the genome-wide significance level (p < 5 × 10

resultsGenetically determined diverticular disease was associated with a higher risk of colorectal cancer (beta = 0.441, 95%CI: 0.081-0.801, P = 0.016) in the FinnGen population, but the association was not found in the UK Biobank (beta = 0.208, 95%CI: -0.291,0.532, P = 0.207). The positive association remained consistent direction in the three sensitivity analyses. In the stratified analysis in the FinnGen consortium, an association was found to exist between genetically predicted diverticular disease and colon cancer (beta = 0.489, 95%CI: 0.020-0.959, P = 0.041), rather than rectum cancer (beta = 0.328, 95%CI: -0.119-0.775, P = 0.151). Besides, we found a slight association between colorectal cancer and diverticular disease (beta = 0.007, 95%CI: 0.004-0.010, P < 0.001) when using colorectal cancer as exposome and diverticular disease as outcome. However, there is a large sample overlap in this step of analysis.

conclusionThis Mendelian randomization study suggests that diverticular disease may be a possible risk factor for colorectal cancer and colon cancer rather than rectum cancer in the FinnGen population.

Indexed as

Colonic NeoplasmsDiverticular DiseasesRectal NeoplasmsGenome-Wide Association StudyHumansMendelian Randomization AnalysisPolymorphism, Single NucleotideColorectal cancerDiverticular diseaseMendelian randomization

Identifiers

PMID36765336
PMCPMC9912649
OpenAlexW4319982193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.