Evidence map›Paper›PMID 36765309›Full record

ArticleBMC public health2023

A factorial experiment grounded in the multiphase optimization strategy to promote viral suppression among people who inject drugs on the Texas-Mexico border: a study protocol.

John A Sauceda, Julia Lechuga, Maria Elena Ramos, Jorge Puentes, Natasha Ludwig-Barron, Jorge Salazar, Katerina A Christopoulos, Mallory O Johnson, David Gomez, Rogelio Covarrubias and 8 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05377463 (Optimizing a Bio-behavioral Intervention to Promote Viral Suppression Among HIV+ People Who Inject Drugs on the U.S.-Mexico Border), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05377463 narecruitingnot on this map

Optimizing a Bio-behavioral Intervention to Promote Viral Suppression Among HIV+ People Who Inject Drugs on the U.S.-Mexico Border

TypeinterventionalSponsorUniversity of Texas, El PasoRan2023 to 2026Enrolled220ConditionsHIV ViremiaArmsPeer support to promote uptake and persistence of medication assisted treatment (MAT), Behavioral Activation Treatment (BAT) to reduce depression, No Intervention Components
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

John A Sauceda *Center for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, 550 16th Street, 94158, San Francisco, CA, USA. john.sauceda@ucsf.edu.
Julia Lechuga *College of Health Sciences, Department of Public Health Sciences, University of Texas at El Paso, 1851 Wiggins Rd., 79968, El Paso, TX, USA.
Maria Elena RamosProgram Compañeros, Cuidad Juárez, Avenue de la Raza 2661, Silvias, Chihuahua, México.
Jorge PuentesCollege of Health Sciences, Department of Public Health Sciences, University of Texas at El Paso, 1851 Wiggins Rd., 79968, El Paso, TX, USA.
Natasha Ludwig-BarronCenter for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, 550 16th Street, 94158, San Francisco, CA, USA.
Jorge SalazarDivision of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, 996 Potrero Avenue, Building 80, 6th Floor, 94110, San Francisco, CA, USA.
Katerina A ChristopoulosDivision of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, 996 Potrero Avenue, Building 80, 6th Floor, 94110, San Francisco, CA, USA.
Mallory O JohnsonCenter for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, 550 16th Street, 94158, San Francisco, CA, USA.
David GomezCentro de Integración Juvenil (CIJ), Cuidad Juárez, Blvd Ing Bernardo Norzagaray, 32130, Cazatecas, Chihuahua, México.
Rogelio CovarrubiasCentro Ambulatorio para la prevención y Atención de SIDA y de las Enfermedades de Transmisión Sexual (CAPASITS), Cuidad Juárez, Avenue Paseo Triunfo de la Republica 3530, 32330, Partido Escobedo, Chihuahua, México.
Joselyn HernandezProgram Compañeros, Cuidad Juárez, Avenue de la Raza 2661, Silvias, Chihuahua, México.
David MontelongoProgram Compañeros, Cuidad Juárez, Avenue de la Raza 2661, Silvias, Chihuahua, México.
Alejandro OrtizProgram Compañeros, Cuidad Juárez, Avenue de la Raza 2661, Silvias, Chihuahua, México.
Julian RojasProgram Compañeros, Cuidad Juárez, Avenue de la Raza 2661, Silvias, Chihuahua, México.
Luisa RamosProgram Compañeros, Cuidad Juárez, Avenue de la Raza 2661, Silvias, Chihuahua, México.
Itzia AvilaProgram Compañeros, Cuidad Juárez, Avenue de la Raza 2661, Silvias, Chihuahua, México.
Marya V GwadzSilver School of Social Work, New York University, 1 Washington Square N, 10003, New York, NY, USA.
Torsten B NeilandsCenter for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, 550 16th Street, 94158, San Francisco, CA, USA.
University of California, San Francisco · USThe University of Texas at El Paso · USCentro Universitario de Ciudad Juárez · MXNew York University · US

Funding

Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 2001 to 2026
$57.4M
TRAINEESHIPS IN AIDS PREVENTION STUDIEST32MH019105 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Carol Suzanne Camlin, Glenn-Milo Santos · 1989 to 2026
$15.3M
Training in HIV Translational ResearchT32AI060530 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Diane V Havlir · 2005 to 2026
$6.4M
Substance Use and HIV Prevention Research in Minority Communities Training ProgramR25DA028567 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Julia Lechuga, Torsten Brian Neilands · 2009 to 2026
$5.4M
Optimizing a bio-behavioral intervention to promote viral suppression among HIV+ people who inject drugs on the U.S.-Mexico borderR01DA053659 · NIDA · UNIVERSITY OF TEXAS EL PASO · PI LECHUGA, JULIA, SAUCEDA, JOHN ANDREW · 2021 to 2025
$3.3M
NIAID NIH HHS T32 AI060530NIDA NIH HHS R01 DA053659NIDA NIH HHS R25 DA028567NIMH NIH HHS P30 MH062246NIMH NIH HHS T32 MH019105
6 · The paper itself

Abstract

backgroundPeople who inject drugs living with HIV (PWIDLH) suffer the lowest rates of HIV viral suppression due to episodic injection drug use and poor mental health coupled with poor retention in HIV care. Approximately 44% of PWIDLH along the US-Mexico border are retained in care and only 24% are virally suppressed. This underserved region faces a potential explosion of transmission of HIV due to highly prevalent injection drug use. This protocol describes an optimization trial to promote sustained viral suppression among Spanish-speaking Latinx PWIDLH.

methodsThe multiphase optimization strategy (MOST) is an engineering-inspired framework for designing and building optimized interventions and guides this intervention. The primary aim is to conduct a 2 DISCUSSION: We are testing well-studied and available intervention components to support PWIDLH to reduce drug use and improve their mental health and engagement in HIV care. The intervention design will allow for a better understanding of how these components work in combination and can be optimized for the setting.

trial registrationThis project was registered at clinicaltrials.gov (NCT05377463) on May 17th, 2022.

Indexed as

Drug UsersHIV InfectionsCounselingHumansMexicoRandomized Controlled Trials as TopicTexasART adherenceBehavioral activation therapy (BAT)Factorial experimentHIV care continuumHIV viral load suppressionLife-stepsMedication-assisted treatment (MAT)Multiphase optimization strategy (MOST)Patient navigationU.S.-Mexico Border

Identifiers

PMID36765309
PMCPMC9921633
OpenAlexW4319959090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.