ArticleBMC pediatrics2023
Comparison of the ability of HOMA-IR, VAI, and TyG indexes to predict metabolic syndrome in children with obesity: a cross-sectional study.
Article in BMC pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Associations between the triglyceride‒glucose index and the odds of low muscle mass and sarcopenia: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- The effect of exercise intervention on the triglyceride-glucose (TyG) index in adolescents with overweight or obesity: a systematic review and Bayesian dose-response meta-analysis.BMC pediatrics · 2025Pooled it
- Assessing the Diagnostic Performance of Triglyceride-Glucose-Based Indices for Early Detection of Metabolic Syndrome in Paediatric Down Syndrome.Journal of intellectual disability research : JIDR · 2026Article
- Sex-specific associations of the triglyceride-glucose index with systemic inflammation and arterial stiffness in adults with normal glucose and triglyceride levels.Atherosclerosis plus · 2026Article
- Clinical utility of a novel index for predicting metabolic dysfunction-associated steatotic liver disease risk in children.European journal of pediatrics · 2026Article
- Metabolic dysfunction and insulin resistance across major dementias: A comprehensive narrative review of the TyG index as a predictive marker.Metabolism open · 2026Review
- Article
- [Metabolic Dysfunction-Associated Steatotic Liver Disease and its association with prediabetes in adolescents with obesity].Revista medica del Instituto Mexicano del Seguro Social · 2026Article
- Triglyceride-glucose-Body Mass Index is linked to papillary thyroid carcinoma odds in China: a retrospective study.Frontiers in endocrinology · 2026Article
- The case for broader use of HOMA-IR in pediatric metabolic assessment: a narrative review.Frontiers in pediatrics · 2026Review
- Cross-lag association between TyG-CVAI and frailty index: evidence from a natural population cohort in southwestern China.Frontiers in public health · 2026Article
- Triglyceride-Glucose Index and the Risk of Calcific Aortic Valve Stenosis: A Bidirectional Mendelian Randomization Study.Anatolian journal of cardiology · 2025Article
- Article
- Age-related insulin resistance changes in children and adolescents and its impact on the accuracy of diagnosis of metabolic syndrome.Annals of pediatric endocrinology & metabolism · 2025Article
- Association between insulin resistance indices and prevalence of knee osteoarthritis using the Korean National health and examination survey.Scientific reports · 2025Article
- Lipid metabolism in overweight/obese children vs. normal weight children in a north-eastern region of Spain.Advances in laboratory medicine · 2025Article
- Article
- Cardiometabolic risk assessment by anthropometric and biochemical indices in mexican population.Frontiers in endocrinology · 2025Article
- Diagnostic value and mediation effects of the visceral adiposity index, triglyceride-glucose index, and platelet-to-HDL ratio in young overweight and obese Chinese adults.Frontiers in nutrition · 2025Article
- E1231/NMN protects against experimental metabolic syndrome: the central role of SIRT1 in modulating AKT/Nrf2/NFκB signaling.Frontiers in pharmacology · 2025Article
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3 authors.
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Abstract
backgroundThe increasing trend in childhood obesity needs to be closely monitored and intervened due to long-term health issues such as metabolic syndrome, cardiovascular diseases, hypertension, and type 2 diabetes. We aimed to determine and compare the cut-off values for the visceral adiposity index (VAI), triglyceride-glucose index (TyG), and HOMA-IR for predicting metabolic syndrome (MetS).
methodsThis population-based cross-sectional study was conducted in May 2019 in Samsun, Turkey. The study included 169 children with obesity aged 9 and 10 years. After anthropometric and clinical evaluation, fasting blood samples were collected from the children. The areas under the curve of the visceral adiposity index, triglyceride-glucose index, and HOMA-IR were compared by receiver-operating-characteristic (ROC) analysis in predicting the MetS.
resultsThe total prevalence of MetS was 21.3% in children with obesity, and it was two times higher in girls than in boys. The mean values of TyG and VAI were significantly different in those who have and have not MetS in both genders. However, the HOMA-IR index was higher only in girls with MetS and did not differ in boys by having MetS. The VAI and the TyG index both had statistically significant cut-off values in both sexes and a larger ROC area than the HOMA-IR index in predicting MetS.
conclusionsThe VAI and TyG index are effective indicators in assessing the MetS risk in children with obesity. Both indexes can be considered useful tools in pediatric research and the evaluation of interventions. However, the HOMA-IR index formula needs to be developed taking into account age, gender, and ethnicity.
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