Evidence map›Paper›PMID 36765296›Full record

ArticleBMC cancer2023

MMP14 expression levels accurately predict the presence of extranodal extensions in oral squamous cell carcinoma: a retrospective cohort study.

Yuri Noda, Mitsuaki Ishida, Ryosuke Yamaka, Yasuhiro Ueno, Tomofumi Sakagami, Takuo Fujisawa, Hiroshi Iwai, Koji Tsuta

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In one paragraph

Article in BMC cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuri NodaDepartment of Pathology and Laboratory Medicine, Kansai Medical University Hospital, 2-3-1 Shin-machi, 573-1191, Hirakata, Osaka, Japan. nodayuridesu@yahoo.co.jp.ORCID http://orcid.org/0000-0001-8041-0074
Mitsuaki IshidaDepartment of Pathology, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, 569-8686, Takatsuki, Osaka, Japan.
Ryosuke YamakaDepartment of Pathology, Kansai Medical University, 2-5-1 Shin-machi, 573- 1010, Hirakata, Osaka, Japan.
Yasuhiro UenoDepartment of Radiology, Kansai Medical University Hospital, 2-3-1 Shinmachi, 573-1191, Hirakata, Osaka, Japan.
Tomofumi SakagamiDepartment of Otolaryngology, Head and Neck Surgery, Kansai Medical University Hospital, 2-3-1 Shinmachi, 573-1191, Hirakata, Osaka, Japan.
Takuo FujisawaDepartment of Otolaryngology, Head and Neck Surgery, Kansai Medical University Hospital, 2-3-1 Shinmachi, 573-1191, Hirakata, Osaka, Japan.
Hiroshi IwaiDepartment of Otolaryngology, Head and Neck Surgery, Kansai Medical University Hospital, 2-3-1 Shinmachi, 573-1191, Hirakata, Osaka, Japan.
Koji TsutaDepartment of Pathology and Laboratory Medicine, Kansai Medical University Hospital, 2-3-1 Shin-machi, 573-1191, Hirakata, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExtranodal extension (ENE) is an adverse prognostic factor for oral squamous cell carcinoma (OSCC), and patients with OSCC along with ENE require neck dissection. In this study, we developed a novel ENE histology-based pathological predictor using MMP14 expression patterns in small biopsy specimens.

methodsA total of 71 surgically resected tissue, 64 dissected lymph node (LN), and 46 biopsy specimens were collected from 71 patients with OSCC. Immunohistochemical analyses of total MMP14 expression in the tumour nest and cancer-associated fibroblasts (CAFs) were performed using the MMP14 co-scoring system (high- or low-risk). The association analysis of MMP14 expression in metastatic LNs was performed with respect to the presence and absence of ENE. Clinicopathological analyses and multivariate examinations were performed to assess the risks of metastasis and ENE presence. The predictive value of ENE and the impact of ENE and MMP14 expression on 5-year overall survival were examined.

resultsHigh-risk MMP14 expression was detected in metastatic LN specimens with ENE. MMP14 expression in tumour nests and CAFs and its overexpression at the tumour-stromal interface significantly correlated with the presence of ENE. The MMP14 co-scoring system was an independent risk predictor for ENE, with sensitivity, specificity, and accuracy of over 80% in biopsy samples; patients with a high risk in the MMP14 co-scoring system had significantly worse prognoses in both resections and biopsies.

conclusionThe MMP14 co-scoring system accurately predicted ENE presence and poor prognosis via immunohistochemical evaluation of small biopsies. This system is a simple, accurate, and inexpensive immunohistochemical approach that can be used in routine pathological diagnosis for effective treatment planning.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsExtranodal ExtensionHumansLymph NodesMatrix Metalloproteinase 14Neoplasm StagingPrognosisRetrospective StudiesSquamous Cell Carcinoma of Head and NeckMatrix Metalloproteinase 14MMP14 protein, humanCancer-associated fibroblastExtranodal extensionMatrix metalloproteinase 14Membrane-type 1 matrix metalloproteinaseOral squamous cell carcinomaPredictor

Identifiers

PMID36765296
PMCPMC9921360

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