ArticleScientific reports2023
A cost-effectiveness evaluation of latent tuberculosis infection screening of a migrant population in Malaysia.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Cost-effectiveness of QuantiFERON for TB infection screening in household contacts in the Philippines.IJTLD open · 2026Article
- Evaluation of TST/C-TST combination for latent tuberculosis infection screening: diagnostic performance and cost-effectiveness compared to TST/IGRAs.BMC infectious diseases · 2026Article
- Optimizing tuberculosis infection screening strategies for people living with HIV in Thailand: a cost-effectiveness analysis.BMC public health · 2025Article
- A cost-effectiveness evaluation of methods for screening for TB infection in patients with diabetes mellitus.IJTLD open · 2025Article
- Article
- Screening of household contacts for TB infection in Cote d'Ivoire.IJTLD open · 2024Article
- A costing framework to compare tuberculosis infection tests.BMJ global health · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To estimate the costs and benefits of screening for latent tuberculosis infection (LTBI) in a migrant population in Malaysia. An economic model was developed from a Malaysian healthcare perspective to compare QuantiFERON-TB Gold Plus (QuantiFERON) with the tuberculin skin test (TST). A decision tree was used to capture outcomes relating to LTBI screening followed by a Markov model that simulated the lifetime costs and benefits of the patient cohort. The Markov model did not capture the impact of secondary infections. The model included an R shiny interactive interface to allow adaptation to other scenarios and settings. QuantiFERON is both more effective and less costly than TST (dominant). Compared with QuantiFERON, the lifetime risk of developing active TB increases by approximately 40% for TST due to missed LTBI cases during screening (i.e. a higher number of false negative cases for TST). For a migrant population in Malaysia, QuantiFERON is cost-effective when compared with TST. Further research should consider targeted LTBI screening for migrants in Malaysia based on common risk factors.
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