ArticleCommunications chemistry2023
Oxygen transfer reaction of haloalkyl amides catalyzed by phenylboronic acid.
Article in Communications chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed, 0 citations in OpenAlex.
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Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Nitrile derivatives are important building blocks in organic synthesis. Herein, we report the serendipitous discovery of an oxygen transfer reaction that produces hydroxyalkyl nitriles from the sequential dehydration and hydrolysis of haloalkyl amides. Product yields of up to 91% were achieved, and the phenylboronic acid was recovered as triphenylboroxine. The triphenylboroxine was reused as a catalyst without any loss of catalytic activity. A probable catalytic pathway was proposed based on control experiments and DFT calculations.
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Registered trials
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