ArticleEuropean journal of nuclear medicine and molecular imaging2023
Secretin modulates appetite via brown adipose tissue-brain axis.
Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03290846 (Secretin Increases Glucose Uptake in Human Brown Adipose Tissue and Induces Satiation.), which is not on this map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Secretin Increases Glucose Uptake in Human Brown Adipose Tissue and Induces Satiation.
Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Intestinal FXR agonism synergizes with leptin to improve obesity by reducing appetite via secretin.EMBO reports · 2026Article
- Brain cannabinoid CB1 receptor signaling modulates reward responses and inhibitory control in humans.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Hormonal Alterations in Individuals with Obesity After Metabolic Bariatric Surgery: A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Dark seasons enhance brain and brown adipose tissue interactions related to mu-opioid receptor signaling.European journal of nuclear medicine and molecular imaging · 2025Article
- Emerging Insights into Brown Adipose Tissue Crosstalk With Pancreatic β-Cells in Metabolic Regulation.Endocrinology · 2025Review
- Review
- Seasonal variation in D2/3 dopamine receptor availability in the human brain.European journal of nuclear medicine and molecular imaging · 2024Article
- Hormone-induced body-brain interaction and the impact on cognition.European journal of nuclear medicine and molecular imaging · 2024Article
- Brown adipocyte and browning thermogenesis: metabolic crosstalk beyond mitochondrial limits and physiological impacts.Adipocyte · 2023Review
- Effects of a long-acting secretin peptide analog alone and in combination with a GLP-1R agonist in a diet-induced obesity mouse model.Molecular metabolism · 2023Article
- The Single-Cell Revelation of Thermogenic Adipose Tissue.Molecules and cells · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
purposeSecretin activates brown adipose tissue (BAT) and induces satiation in both mice and humans. However, the exact brain mechanism of this satiety inducing, secretin-mediated gut-BAT-brain axis is largely unknown. METHODS AND
resultsIn this placebo-controlled, single-blinded neuroimaging study, firstly using [
conclusionThese findings suggest that secretin may modulate the BAT-brain metabolic crosstalk and subsequently the neurometabolic coupling to induce satiation. The study advances our understanding of the secretin signaling in motivated eating behavior and highlights the potential role of secretin in treating eating disorders and obesity.
trial registrationEudraCT no. 2016-002373-35, registered 2 June 2016; Clinical Trials no. NCT03290846, registered 25 September 2017.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.