Evidence map›Paper›PMID 36764943›Full record

ArticleActa neuropathologica2023

Dysregulation of astrocytic Ca

Carmen Nanclares, Jonah Poynter, Hector A Martell-Martinez, Scott Vermilyea, Alfonso Araque, Paulo Kofuji, Michael K Lee, Ana Covelo

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Acta neuropathologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Astrocyte alterations in α-synucleinopathies.Frontiers in cellular neuroscience · 2025
    Review
  10. Review
  11. Article
  12. A Plant Model ofApplied biosciences · 2024
    Article
  13. Article
  14. Article
  15. Astrocytic modulation of neuronal signalling.Frontiers in network physiology · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Carmen NanclaresDepartment of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.
Jonah PoynterDepartment of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.
Hector A Martell-MartinezDepartment of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.
Scott VermilyeaDepartment of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.
Alfonso AraqueDepartment of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.
Paulo Kofuji *Department of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA. kofuj001@umn.edu.
Michael K Lee *Department of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA. mklee@umn.edu.
Ana Covelo *Department of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA. ana.covelo@inserm.fr.ORCID 0000-0002-9121-8632
University of Minnesota · US

Funding

Tau-dependent cognitive deficits in alpha-synucleinopathiesR01NS108686 · NINDS · UNIVERSITY OF MINNESOTA · PI ARAQUE, ALFONSO, LEE, MICHAEL K · 2018 to 2022
$2.8M
Astrocyte activity in amygdala-related fear conditioned behaviorsR01MH119355 · NIMH · UNIVERSITY OF MINNESOTA · PI ARAQUE, ALFONSO, KOFUJI, PAULO · 2020 to 2024
$2.3M
Pathological role of c-Abl in alpha-synucleinoapathyR01NS092093 · NINDS · UNIVERSITY OF MINNESOTA · PI LEE, MICHAEL K · 2016 to 2020
$2.2M
Role of astrocytes in dopamine signaling and psychostimulant effectsR01DA048822 · NIDA · UNIVERSITY OF MINNESOTA · PI ARAQUE, ALFONSO · 2019 to 2023
$1.8M
Astrocyte-neuron interaction in behavior driven by striatal information processingR01NS097312 · NINDS · UNIVERSITY OF MINNESOTA · PI ARAQUE, ALFONSO, REDISH, A DAVID · 2016 to 2019
$1.8M
Unfolded Protein Response in Alpha-synucleinopathiesR01NS086074 · NINDS · UNIVERSITY OF MINNESOTA · PI LEE, MICHAEL K · 2014 to 2018
$1.7M
Alpha-Synuclein Induced Network Hyperexcitability in Lewy Body DementiasR56AG074473 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEE, MICHAEL K, MOORE, DARREN JOHN · 2021 to 2021
$840k
Role of alpha-synuclein-dependent network hyperactivity in Lewy Body DementiaR56NS113549 · NINDS · UNIVERSITY OF MINNESOTA · PI LEE, MICHAEL K · 2019 to 2019
$766k
NIA NIH HHS R56 AG074473NIDA NIH HHS R01 DA048822NIMH NIH HHS R01 MH119355NINDS NIH HHS R01 NS086074NINDS NIH HHS R01 NS092093NINDS NIH HHS R01 NS097312NINDS NIH HHS R01 NS108686NINDS NIH HHS R56 NS113549
6 · The paper itself

Abstract

α-Synuclein is a major component of Lewy bodies (LB) and Lewy neurites (LN) appearing in the postmortem brain of Parkinson's disease (PD) and other α-synucleinopathies. While most studies of α-synucleinopathies have focused on neuronal and synaptic alterations as well as dysfunctions of the astrocytic homeostatic roles, whether the bidirectional astrocyte-neuronal communication is affected in these diseases remains unknown. We have investigated whether the astrocyte Ca

Indexed as

Parkinson DiseaseSynucleinopathiesalpha-SynucleinAnimalsAstrocytesDisease Models, AnimalHumansMiceMice, Transgenicalpha-SynucleinAstrocyteCalciumGliotransmissionSynucleinopathiesα-synuclein

Identifiers

PMID36764943
PMCPMC10119048
OpenAlexW4319870803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.