ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2023
Development and validation of the lung donor (LUNDON) acceptability score for pulmonary transplantation.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 12 citations in OpenAlex.
- The utility of machine learning for predicting donor non-use in lung transplantation.JHLT open · 2026Article
- Development and Validation of a Computed Tomography-Based Convolutional Neural Network Model for Assisting Donor Lung Acquisition in Lung Transplantation.Journal of imaging informatics in medicine · 2026Article
- The addition of computed tomography (CT) findings maintains the predictive performance of an existing radiograph-based donor lung acceptability score.The Journal of thoracic and cardiovascular surgery · 2026Article
- Maximizing Lung Transplant Donor Utilization: Developing a Lobar Donor Repository Guided by Chest Computed Tomography Visual Scoring.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Article
- Association Between Three Lung Donor Scores and Lung Acceptance in DBD and DCD Donors.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Impact of Mild-to-Moderate Donor Lung Infiltration on Post-lung Transplant Survival Outcomes and Risk Factors: A National Cohort Study.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Article
- Outcomes associated with remote, centralized ex vivo lung perfusion (rc-EVLP) for donor lungs in a real-world setting.JTCVS open · 2025Article
- Application and validation of a newly developed lung donor (LUNDON) acceptability score for lung transplantation: a retrospective cohort study.Journal of thoracic disease · 2025Article
- Use of a novel donor lung scoring system as a tool for increasing lung recovery for transplantation.The Journal of thoracic and cardiovascular surgery · 2025Article
- Validation of a novel donor lung scoring system based on the updated lung Composite Allocation Score.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Lung Donation and Transplant Recipient Outcomes at Independent vs Hospital-Based Donor Care Units.JAMA network open · 2024Article
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Authors and funding
19 authors at 1 institution in 1 country.
Funding
Abstract
There is a chronic shortage of donor lungs for pulmonary transplantation due, in part, to low lung utilization rates in the United States. We performed a retrospective cohort study using data from the Scientific Registry of Transplant Recipients database (2006-2019) and developed the lung donor (LUNDON) acceptability score. A total of 83 219 brain-dead donors were included and were randomly divided into derivation (n = 58 314, 70%) and validation (n = 24 905, 30%) cohorts. The overall lung acceptance was 27.3% (n = 22 767). Donor factors associated with the lung acceptance were age, maximum creatinine, ratio of arterial partial pressure of oxygen to fraction of inspired oxygen, mechanism of death by asphyxiation or drowning, history of cigarette use (≥20 pack-years), history of myocardial infarction, chest x-ray appearance, bloodstream infection, and the occurrence of cardiac arrest after brain death. The prediction model had high discriminatory power (C statistic, 0.891; 95% confidence interval, 0.886-0.895) in the validation cohort. We developed a web-based, user-friendly tool (available at https://sites.wustl.edu/lundon) that provides the predicted probability of donor lung acceptance. LUNDON score was also associated with recipient survival in patients with high lung allocation scores. In conclusion, the multivariable LUNDON score uses readily available donor characteristics to reliably predict lung acceptability. Widespread adoption of this model may standardize lung donor evaluation and improve lung utilization rates.
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