ArticleMolecular cell2023
Mechanism of signal-anchor triage during early steps of membrane protein insertion.
Article in Molecular cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- AATRhg1 is a tonoplast protein that alters amino acid, metabolic, and defense responses and nematode resistance.Plant physiology · 2026Article
- Pairwise transmembrane domain insertion during multipass protein biogenesis.Molecular cell · 2026Article
- Design principles of human membrane protein topology.The Journal of cell biology · 2026Article
- Membrane Protein Insertion in Cells: Principles, Pathways, and Quality Control.Chemical reviews · 2026Review
- Signal recognition particle-dependent secretome in humans.Scientific reports · 2026Article
- Genome-wide identification, characterization, and expression analyses of the solute carrier 2 (SLC2) gene family in fall armyworm (Spodoptera frugiperda).BMC genomics · 2026Article
- SARS-CoV-2 membrane protein biogenesis.bioRxiv : the preprint server for biology · 2026Article
- Transmembrane effector substrates of type IV secretion systems: mechanisms of secretion and insertion into host cell membranes.microLife · 2026Review
- Rules of Engagement for Components of Membrane Protein Biogenesis at the Human Endoplasmic Reticulum.International journal of molecular sciences · 2025Review
- Cryptosporidium parvum protease INS6 plays an important role in parasite proliferation and pathogenicity.PLoS neglected tropical diseases · 2025Article
- The EMC acts as a chaperone for membrane proteins.Nature communications · 2025Article
- The Epstein-Barr virus deubiquitinase BPLF1 regulates stress-induced ribosome UFMylation and reticulophagy.Autophagy · 2025Article
- Inhibition of TSH Receptor Expression by a Cyclotriazadisulfonamide as a Potential Treatment of Graves Hyperthyroidism.Endocrinology · 2025Article
- Privileged proteins with a second residence: dual targeting and conditional re-routing of mitochondrial proteins.The FEBS journal · 2024Review
- Identification of a factor that accelerates substrate release from the signal recognition particle.Science (New York, N.Y.) · 2024Article
- Features of membrane protein sequence direct post-translational insertion.Nature communications · 2024Article
- A unifying model for membrane protein biogenesis.Nature structural & molecular biology · 2024Review
- Article
- APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size.The Journal of cell biology · 2024Article
- EMC rectifies the topology of multipass membrane proteins.Nature structural & molecular biology · 2024Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Most membrane proteins use their first transmembrane domain, known as a signal anchor (SA), for co-translational targeting to the endoplasmic reticulum (ER) via the signal recognition particle (SRP). The SA then inserts into the membrane using either the Sec61 translocation channel or the ER membrane protein complex (EMC) insertase. How EMC and Sec61 collaborate to ensure SA insertion in the correct topology is not understood. Using site-specific crosslinking, we detect a pre-insertion SA intermediate adjacent to EMC. This intermediate forms after SA release from SRP but before ribosome transfer to Sec61. The polypeptide's N-terminal tail samples a cytosolic vestibule bordered by EMC3, from where it can translocate across the membrane concomitant with SA insertion. The ribosome then docks on Sec61, which has an opportunity to insert those SAs skipped by EMC. These results suggest that EMC acts between SRP and Sec61 to triage SAs for insertion during membrane protein biogenesis.
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Registered trials
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