ArticleScience advances2023
Motion lubrication suppressed mechanical activation via hydrated fibrous gene patch for tendon healing.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 67 citations in OpenAlex.
- Application of hydrogel technologies in the treatment of musculoskeletal disorders.Chinese medical journal · 2026Review
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- Programmable Hydrogels for Surgical Interface Control: Function-Based Design, DNA-Based Molecular Modules, and Translational Evaluation.Gels (Basel, Switzerland) · 2026Review
- Spatiotemporal acoustic meta-patches for multifactorial wound treatment.Bioactive materials · 2026Article
- Bidirectionally Thermochromic Nanocolloid System for on-Demand Optical Switching and Agricultural Energy Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Design Considerations, Formulation Approaches, and Strategic Advances of Hydrogel Platforms for Tendinopathy Management.Biomaterials research · 2026Review
- A bio-adaptive physical hydrogel enables dynamic tissue engineering for tracheal reconstruction.Nature communications · 2025Article
- The Composite Antiadhesion Barrier Facilitated Fibroblast Autophagy Activation for Tendon Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Injectable composite microspheres/hydrogel membranes for Achilles tendon regeneration.Materials today. Bio · 2025Article
- Biomaterial-Based Nucleic Acid Delivery Systems for In Situ Tissue Engineering and Regenerative Medicine.International journal of molecular sciences · 2025Review
- Historical evolution, hotspots, and trends in tendon tissue engineering: A bibliometric analysis.Regenerative therapy · 2025Article
- One-Step Formed Janus Hydrogel with Time-Space Regulating Properties for Suture-Free and High-Quality Tendon Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Injectable bioadhesive and lubricating hydrogel with polyphenol mediated single atom nanozyme for rheumatoid arthritis therapy.Nature communications · 2025Article
- Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction.Bioactive materials · 2025Article
- A motion-responsive injectable lubricative hydrogel for efficient Achilles tendon adhesion prevention.Materials today. Bio · 2025Article
- Bridging immune-neurovascular crosstalk via the immunomodulatory microspheres for promoting neural repair.Bioactive materials · 2025Article
- Solid-Liquid Interface Lubricating Hydrogels for Tendon-Bone Healing.Research (Washington, D.C.) · 2025Article
- Unidirectional gene delivery electrospun fibrous membrane via charge repulsion for tendon repair.Bioactive materials · 2024Article
- Long-acting anti-inflammatory injectable DEX-Gel with sustained release and self-healing properties regulates TJournal of nanobiotechnology · 2024Article
- Regulating Blood Clot Fibrin Films to Manipulate Biomaterial-Mediated Foreign Body Responses.Research (Washington, D.C.) · 2023Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanical activation of fibroblasts, caused by friction and transforming growth factor-β1 recognition, is one of the main causes of tissue adhesions. In this study, we developed a lubricated gene-hydrogel patch, which provides both a motion lubrication microenvironment and gene therapy. The patch's outer layer is composed of polyethylene glycol polyester hydrogel. The hydrogel forms hydrogen bonds with water molecules to create the motion lubrication layer, and it also serves as a gene delivery library for long-term gene silencing. Under the motion lubricated microenvironment, extracellular signal-regulated kinase-small interfering RNA can silence fibroblasts and enhance the blocking effect against fibroblast activation. In vitro, the proposed patch effectively inhibits fibroblast activation and reduces the coefficient of friction. In vivo, this patch reduces the expression of vimentin and α-smooth muscle actin in fibroblasts. Therefore, the lubricated gene-hydrogel patch can inhibit the mechanical activation of fibroblasts to promote tendon healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.