ArticleHuman brain mapping2023
Combining arterial blood contrast with BOLD increases fMRI intracortical contrast.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Article
- Impact of thermal and physiological denoising on laminar functional connectivity.Scientific reports · 2026Article
- Mesoscale imaging of the human cerebellum reveals converging regional specialization of its morphology, vasculature, and cytoarchitecture.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cerebellar imaging for neuroscience at 9.4 T.Magnetic resonance in medicine · 2025Article
- Does the Cortical-Depth Dependence of the Hemodynamic Response Function Differ Between Age Groups?Brain topography · 2025Article
- Blood nulling versus tissue suppression: Enhancing integrated VASO and perfusion (VAPER) contrast for laminar fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Combining arterial blood contrast with BOLD increases fMRI intracortical contrast.Human brain mapping · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
BOLD fMRI is widely applied in human neuroscience but is limited in its spatial specificity due to a cortical-depth-dependent venous bias. This reduces its localization specificity with respect to neuronal responses, a disadvantage for neuroscientific research. Here, we modified a submillimeter BOLD protocol to selectively reduce venous and tissue signal and increase cerebral blood volume weighting through a pulsed saturation scheme (dubbed Arterial Blood Contrast) at 7 T. Adding Arterial Blood Contrast on top of the existing BOLD contrast modulated the intracortical contrast. Isolating the Arterial Blood Contrast showed a response free of pial-surface bias. The results suggest that Arterial Blood Contrast can modulate the typical fMRI spatial specificity, with important applications in in-vivo neuroscience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.