Evidence map›Paper›PMID 36763538›Full record

ArticleBlood advances2023

BH3 profiling identifies BCL-2 dependence in adult patients with early T-cell progenitor acute lymphoblastic leukemia.

Elyse A Olesinski, Karanpreet S Bhatia, Aarthi N Mahesh, Shazwina Rosli, Jameelah S Mohamed, Wei Y Jen, Nitin Jain, Jacqueline S Garcia, Gee C Wong, Melissa Ooi and 3 more

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Genomic Subtype Influences BH3 Mimetic Drug Sensitivity and Synergy with Cytotoxic Chemotherapeutics in T-cell Acute Lymphoblastic Leukemia.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  4. Article
  5. Pandora's Box of AML: HowBiomedicines · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Elyse A OlesinskiDeparment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
Karanpreet S BhatiaDepartment of Pharmacy, National University of Singapore, Singapore, Singapore.
Aarthi N MaheshDepartment of Pharmacy, National University of Singapore, Singapore, Singapore.
Shazwina RosliDepartment of Pharmacy, National University of Singapore, Singapore, Singapore.
Jameelah S MohamedDepartment of Hematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore.
Wei Y JenDepartment of Hematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore.ORCID 0000-0002-9339-3362
Nitin JainDepartment of Leukemia, MD Anderson Cancer Center, Houston, TX.
Jacqueline S GarciaDeparment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0003-2118-6302
Gee C WongDepartment of Hematology, Singapore General Hospital, Singapore, Singapore.
Melissa OoiDepartment of Hematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore.ORCID 0000-0002-7392-0655
Anthony LetaiDeparment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
Marina KonoplevaDepartment of Leukemia, MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-9347-2212
Shruti BhattDepartment of Pharmacy, National University of Singapore, Singapore, Singapore.
National University of Singapore · SGDana-Farber Cancer Institute · USNational University Cancer Institute, Singapore · SGThe University of Texas MD Anderson Cancer Center · USSingapore General Hospital · SG

Funding

TYROSINE KINASE ONCOGENESIS IN MYELOID LEUKEMIAP01CA066996 · NCI · DANA-FARBER CANCER INSTITUTE · PI SCOTT A ARMSTRONG · 1996 to 2026
$52.5M
Targeting SYK Kinase in AMLP50CA206963 · NCI · DANA-FARBER CANCER INST · PI STEGMAIER, KIMBERLY · 2017 to 2021
$10.6M
Inhibition of Bcl-xL by Targeted DegradationR01CA241191 · NCI · UNIVERSITY OF FLORIDA · PI KONOPLEVA, MARINA Y, ZHENG, GUANGRONG · 2020 to 2024
$2.6M
Enhancing Venetoclax Activity in Chemoresistant Acute Myeloid LeukemiaK08CA245209 · NCI · DANA-FARBER CANCER INST · PI GARCIA, JACQUELINE SUEN · 2020 to 2024
$1.3M
NCI NIH HHS K08 CA245209NCI NIH HHS P01 CA066996NCI NIH HHS P50 CA206963NCI NIH HHS R01 CA241191
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Precursor T-Cell Lymphoblastic Leukemia-LymphomaProto-Oncogene Proteins c-bcl-2AdultHumansT-LymphocytesProto-Oncogene Proteins c-bcl-2

Identifiers

PMID36763538
PMCPMC10285538
OpenAlexW4319826235

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.