Evidence map›Paper›PMID 36763530›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

The human proton pump inhibitors inhibit

M Alexandra Lake, Kristin N Adams, Feilin Nie, Elaine Fowler, Amit K Verma, Silvia Dei, Elisabetta Teodori, David R Sherman, Paul H Edelstein, David R Spring and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Article
  3. CRISPRi-mediated silencing of the ABC transporterFrontiers in microbiology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Verapamil and its metabolite norverapamil inhibit theProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Drug-TolerantInternational journal of molecular sciences · 2023
    Article
  15. Profile of Lalita Ramakrishnan.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

M Alexandra LakeMolecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, CB2 0AW Cambridge, UK.ORCID 0000-0003-3265-0078
Kristin N AdamsDepartment of Microbiology, University of Washington, Seattle 98195.
Feilin NieYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Elaine FowlerYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Amit K VermaMolecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, CB2 0AW Cambridge, UK.
Silvia DeiDepartment of Neuroscience, Psychology, Drug Research and Child Health - Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, 50019 Sesto Fiorentino (FI), Italy.
Elisabetta TeodoriDepartment of Neuroscience, Psychology, Drug Research and Child Health - Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, 50019 Sesto Fiorentino (FI), Italy.
David R ShermanDepartment of Microbiology, University of Washington, Seattle 98195.
Paul H EdelsteinMolecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, CB2 0AW Cambridge, UK.ORCID 0000-0002-4069-5279
David R SpringYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.ORCID 0000-0001-7355-2824
Mark TrollMolecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, CB2 0AW Cambridge, UK.
Lalita RamakrishnanMolecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, CB2 0AW Cambridge, UK.ORCID 0000-0003-0692-5533
Johns Hopkins University · USMRC Laboratory of Molecular Biology · GBUniversity of Cambridge · GBUniversity of Washington · US

Funding

Technology CoreU19AI135976 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI ADEREM, ALAN A · 2018 to 2022
$17.0M
Systems Biology CoreU19AI162598 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI RUSSELL, DAVID G · 2021 to 2025
$13.9M
Host Responses to Mycobacterium Infection in ZebrafishR01AI054503 · NIAID · UNIVERSITY OF WASHINGTON · PI LALITA RAMAKRISHNAN · 2003 to 2026
$4.4M
Genetic, Metabolic and Regulatory Control of MIC and Relapse in M. tuberculosisR01AI146194 · NIAID · UNIVERSITY OF WASHINGTON · PI ALLAND, DAVID, SHERMAN, DAVID R · 2020 to 2024
$4.1M
Host-Responses to Mycobacterium Infection in ZebrafishR37AI054503 · NIAID · UNIVERSITY OF WASHINGTON · PI RAMAKRISHNAN, LALITA · 2012 to 2021
$3.1M
A multifactorial pipeline to dissect combinatorial drug efficacy in TuberculosisR01AI150826 · NIAID · UNIVERSITY OF WASHINGTON · PI SHERMAN, DAVID R · 2021 to 2024
$2.9M
NIAID NIH HHS R01 AI054503NIAID NIH HHS R01 AI146194NIAID NIH HHS R01 AI150826NIAID NIH HHS R37 AI054503NIAID NIH HHS U19 AI135976NIAID NIH HHS U19 AI162598Wellcome Trust 211145/Z/18/ZWellcome Trust 223103Wellcome Trust 223103/Z/21/Z
6 · The paper itself

Abstract

Tuberculosis treatment requires months-long combination chemotherapy with multiple drugs, with shorter treatments leading to relapses. A major impediment to shortening treatment is that

Indexed as

Mycobacterium tuberculosisTuberculosisAntitubercular AgentsBacterial ProteinsDrug ToleranceHumansMacrophagesMicrobial Sensitivity TestsProton Pump InhibitorsRifampinVerapamilAntitubercular AgentsBacterial ProteinsProton Pump InhibitorsRifampinVerapamilefflux pump inhibitorsmycobacterial efflux pumpsproton pump inhibitorstuberculosis rifampicin toleranceverapamil

Identifiers

PMID36763530
PMCPMC7614234
OpenAlexW4319827638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.