Evidence map›Paper›PMID 36763300›Full record

ArticleJournal of assisted reproduction and genetics2023

Trends in the incidence of major birth defects after assisted reproductive technologies in Lombardy Region, Northern Italy.

Giulia Galati, Giovanna Esposito, Edgardo Somigliana, Ludovico Muzii, Matteo Franchi, Giovanni Corrao, Fabio Parazzini

Abstract read
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In one paragraph

Article in Journal of assisted reproduction and genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giulia GalatiDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy. giulia.galati@uniroma1.it.ORCID http://orcid.org/0000-0002-5289-4013
Giovanna EspositoDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Edgardo SomiglianaDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy. dadosomigliana@yahoo.it.
Ludovico MuziiDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Matteo FranchiLaboratory of Healthcare Research & Pharmacoepidemiology, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy.
Giovanni CorraoLaboratory of Healthcare Research & Pharmacoepidemiology, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy.
Fabio ParazziniDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Funding

Ministero della Salute 'PRIN' 2017, project 2017728JPK
6 · The paper itself

Abstract

purposeThe incidence of birth defects is increased in children born after assisted reproductive technologies (ART). However, changes in ART over time could influence this incidence. To investigate this issue, we present the frequency and trends of birth defects in ART and natural pregnancies in Lombardy, Northern Italy, during the period 2014-2020.

methodsThis is a population-based study using automated system of healthcare utilization (HCU) databases. ART pregnancies included only those obtained with conventional IVF or ICSI. After identifying the total number of deliveries, the rate of newborns with birth defects was compared between natural and ART pregnancies. A logistic regression model was used to calculate the adjusted odd ratio (OR). Analyses were repeated for every calendar year.

resultsOverall, 508,421 deliveries were identified, of which 14,067 (2.8%) were achieved after IVF-ICSI. A decreasing trend in birth defects over time was highlighted. The adjusted OR dropped from 1.40 (95%CI: 1.03-1.91) in 2014 to 0.92 (95%CI: 0.69-1.22) in 2020. During the study period, a significant reduction in multiple pregnancy and in the ratio of ICSI to conventional IVF was also observed, explaining at least in part the positive trend observed for birth defects.

conclusionThe increased risk of birth defects in children born after IVF-ICSI is not steady over time. A decline of this risk emerged in our region. Policy changes in ART may explain this beneficial effect.

Indexed as

Pregnancy, MultipleReproductive Techniques, AssistedChildFemaleHumansIncidenceInfant, NewbornItalyLogistic ModelsPregnancyRetrospective StudiesBirth defectsCongenital malformationICSIIVFMultiple pregnancy

Identifiers

PMID36763300
PMCPMC10224879

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.