Evidence map›Paper›PMID 36763212›Full record

ArticleCellular and molecular life sciences : CMLS2023

Co-dependent regulation of p-BRAF and potassium channel KCNMA1 levels drives glioma progression.

Shanshan Xie, Chengyan Xu, Cheng Wu, Yuhan Lou, Jingwei Duan, Rong Sang, Ziwei Lou, Jiaru Hou, Wanzhong Ge, Yongmei Xi and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Pro-tumoral CaScientific reports · 2026
    Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Shanshan Xie *The Women's Hospital, Institute of Genetics, Zhejiang Provincial Key Laboratory of Genetic and Development Disorders, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Chengyan Xu *Department of Neurosurgery, The Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China.
Cheng WuThe Women's Hospital, Institute of Genetics, Zhejiang Provincial Key Laboratory of Genetic and Development Disorders, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Yuhan LouThe Women's Hospital, Institute of Genetics, Zhejiang Provincial Key Laboratory of Genetic and Development Disorders, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Jingwei DuanThe Women's Hospital, Institute of Genetics, Zhejiang Provincial Key Laboratory of Genetic and Development Disorders, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Rong SangThe Women's Hospital, Institute of Genetics, Zhejiang Provincial Key Laboratory of Genetic and Development Disorders, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Ziwei LouThe Women's Hospital, Institute of Genetics, Zhejiang Provincial Key Laboratory of Genetic and Development Disorders, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Jiaru HouThe Women's Hospital, Institute of Genetics, Zhejiang Provincial Key Laboratory of Genetic and Development Disorders, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Wanzhong GeThe Women's Hospital, Institute of Genetics, Zhejiang Provincial Key Laboratory of Genetic and Development Disorders, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Yongmei XiThe Women's Hospital, Institute of Genetics, Zhejiang Provincial Key Laboratory of Genetic and Development Disorders, School of Medicine, Zhejiang University, Hangzhou, 310058, China. xyyongm@zju.edu.cn.ORCID http://orcid.org/0000-0001-7374-2564
Xiaohang YangThe Women's Hospital, Institute of Genetics, Zhejiang Provincial Key Laboratory of Genetic and Development Disorders, School of Medicine, Zhejiang University, Hangzhou, 310058, China. xhyang@zju.edu.cn.ORCID http://orcid.org/0000-0001-5192-5706
Women's Hospital, School of Medicine, Zhejiang University · CNChildren's Hospital of Zhejiang University · CN

Funding

National Key R&D Program of China 2013CB945601National Key R&D Program of China 2018YFC1004904
6 · The paper itself

Abstract

BRAF mutations have been found in gliomas which exhibit abnormal electrophysiological activities, implying their potential links with the ion channel functions. In this study, we identified the Drosophila potassium channel, Slowpoke (Slo), the ortholog of human KCNMA1, as a critical factor involved in dRaf

Indexed as

GliomaLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsProto-Oncogene Proteins B-rafAnimalsDrosophilaDrosophila ProteinsHEK293 CellsHumansLarge-Conductance Calcium-Activated Potassium ChannelsPotassium ChannelsBRAF protein, humanDrosophila ProteinsKCNMA1 protein, humanLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsPotassium ChannelsProto-Oncogene Proteins B-rafslo protein, DrosophilaBRAFGliomaKCNMA1Potassium channel

Identifiers

PMID36763212
PMCPMC9918570
OpenAlexW4319812484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.