Evidence map›Paper›PMID 36763150›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2023

Relationship between the severity of olfactory dysfunction and serum zinc levels.

Hirotaka Tanaka, Eri Mori, Rumi Sekine, Nagomi Yonezawa, Masayoshi Tei, Nobuyoshi Otori

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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Association between dietary zinc intake and olfactory dysfunction: a study based on the NHANES database.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hirotaka TanakaDepartment of Otorhinolaryngology, Jikei University School of Medicine, 3-25-8, Nishishimbashi, Minato-Ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5322-5479
Eri MoriDepartment of Otorhinolaryngology, Jikei University School of Medicine, 3-25-8, Nishishimbashi, Minato-Ku, Tokyo, Japan. morieri@jikei.ac.jp.ORCID http://orcid.org/0000-0003-3273-3789
Rumi SekineDepartment of Otorhinolaryngology, The Jikei University Daisan Hospital, Tokyo, Japan.
Nagomi YonezawaDepartment of Otorhinolaryngology, Jikei University School of Medicine, 3-25-8, Nishishimbashi, Minato-Ku, Tokyo, Japan.
Masayoshi TeiDepartment of Otorhinolaryngology, Jikei University School of Medicine, 3-25-8, Nishishimbashi, Minato-Ku, Tokyo, Japan.
Nobuyoshi OtoriDepartment of Otorhinolaryngology, Jikei University School of Medicine, 3-25-8, Nishishimbashi, Minato-Ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlthough the association between zinc deficiency and olfactory dysfunction is inconclusive, zinc deficiency causes apoptosis of the olfactory ensheathing cells which is involved in olfactory nerve turnover and axon regeneration, thereby suggesting a possible relationship. We investigated the relationship between serum zinc levels and olfactory function in patients with olfactory dysfunction.

methodsNinety patients who had been diagnosed with post-infectious, posttraumatic, drug-induced, neurological and idiopathic olfactory dysfunction were included. Patients were divided into zinc normal group and zinc deficiency groups according to three reference values for serum zinc levels (60, 65, 70 µg/dL). The results of olfactory tests and patient backgrounds were used to compare the differences between the two groups.

resultsThere were significantly worse detection and recognition thresholds in the T&T olfactometer and Open Essence (odor identification test) results in the zinc deficiency group (< 60 µg/dL). In addition, significant correlations between olfactory tests (detection/recognition thresholds in the T&T olfactometer and Open Essence results) and serum zinc levels < 65 µg/dL were observed. The zinc deficiency group < 70 µg/dL with idiopathic olfactory dysfunction had significantly worse olfactory tests (detection/recognition thresholds in the T&T olfactometer and Open Essence). In addition, there was a significant correlation between the detection/recognition thresholds in the T&T olfactometer and serum zinc levels in idiopathic olfactory dysfunction.

conclusionsOur findings suggest that zinc deficiency may exacerbate the severity of olfactory dysfunction. Furthermore, idiopathic olfactory dysfunction may be partly caused by zinc deficiency.

Indexed as

MalnutritionOlfaction DisordersAxonsHumansNerve RegenerationSmellZincZincHematologic testsOlfaction disordersOlfactory nerve diseasesZinc deficiency

Identifiers

PMID36763150

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.