Evidence map›Paper›PMID 36763096›Full record

ArticleDatabase : the journal of biological databases and curation2023

Coronavirus Immunotherapeutic Consortium Database.

Jarjapu Mahita, Brendan Ha, Anais Gambiez, Sharon L Schendel, Haoyang Li, Kathryn M Hastie, S Moses Dennison, Kan Li, Natalia Kuzmina, Sivakumar Periasamy and 20 more

Abstract read
In one paragraph

Article in Database : the journal of biological databases and curation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. A comprehensive experimental comparison between federated and centralized learning.Database : the journal of biological databases and curation · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Targeting spike glycans to inhibit SARS-CoV2 viral entry.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Jarjapu MahitaCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.ORCID 0000-0002-2030-3944
Brendan HaCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Anais GambiezCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Sharon L SchendelCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Haoyang LiCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Kathryn M HastieCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
S Moses DennisonCenter for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA.ORCID 0000-0003-1198-9179
Kan LiCenter for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA.
Natalia KuzminaDepartment of Pathology, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555-0609, USA.
Sivakumar PeriasamyDepartment of Pathology, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555-0609, USA.
Alexander BukreyevDepartment of Pathology, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555-0609, USA.
Jennifer E MuntDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 135 Dauer Drive, 2101 McGavran-Greenberg Hall,CB #7435, Chapel Hill, NC 27599-7435, USA.
Mary Osei-TwumNexelis, a Q2 Solutions Company, 525 Boulevard Cartier Ouest, Laval, Quebec H7V 3S8, Canada.
Caroline AtyeoRagon Institute of MGH, MIT and Harvard, 400 Technology Square, Cambrige, MA 02139-3583, USA.
James A OvertonKnocean Inc., 107 Quebec Ave. Toronto, Ontario, M6P 2T3, Canada.ORCID 0000-0001-5139-5557
Randi VitaCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Hector Guzman-OrozcoCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Marcus MendesCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Mari KojimaCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Peter J HalfmannInfluenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, WI 53711, USA.
Yoshihiro KawaokaInfluenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, WI 53711, USA.
Galit AlterRagon Institute of MGH, MIT and Harvard, 400 Technology Square, Cambrige, MA 02139-3583, USA.ORCID 0000-0002-7680-9215
Luc GagnonNexelis, a Q2 Solutions Company, 525 Boulevard Cartier Ouest, Laval, Quebec H7V 3S8, Canada.
Ralph S BaricDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 135 Dauer Drive, 2101 McGavran-Greenberg Hall,CB #7435, Chapel Hill, NC 27599-7435, USA.
Georgia D TomarasCenter for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA.
Tim GermannCarterra Inc., 825 N. 300 W.Ste, C309, Salt Lake City, UT 84103, USA.
Daniel BedingerCarterra Inc., 825 N. 300 W.Ste, C309, Salt Lake City, UT 84103, USA.
Jason A GreenbaumCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Erica Ollmann SaphireCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Bjoern PetersCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.ORCID 0000-0002-8457-6693

Funding

Specific and Broadly Active Monoclonal Antibody Therapeutics Against The FilovirusesU19AI142790 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SAPHIRE, ERICA OLLMANN · 2019 to 2023
$40.0M
Gates Foundation INV-017270National Institute of Allergy and Infectious Diseases U19AI142790NIAID NIH HHS U19 AI142790Wellcome Trust
6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has seen multiple anti-SARS-CoV-2 antibodies being generated globally. It is difficult, however, to assemble a useful compendium of these biological properties if they are derived from experimental measurements performed at different sites under different experimental conditions. The Coronavirus Immunotherapeutic Consortium (COVIC) circumvents these issues by experimentally testing blinded antibodies side by side for several functional activities. To collect these data in a consistent fashion and make it publicly available, we established the COVIC database (COVIC-DB, https://covicdb.lji.org/). This database enables systematic analysis and interpretation of this large-scale dataset by providing a comprehensive view of various features such as affinity, neutralization, in vivo protection and effector functions for each antibody. Interactive graphs enable direct comparisons of antibodies based on select functional properties. We demonstrate how the COVIC-DB can be utilized to examine relationships among antibody features, thereby guiding the design of therapeutic antibody cocktails. Database URL  https://covicdb.lji.org/.

Indexed as

COVID-19Antibodies, ViralHumansImmunotherapySARS-CoV-2Antibodies, Viral

Identifiers

PMID36763096
PMCPMC9913043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.