Evidence map›Paper›PMID 36763080›Full record

ArticleeLife2023

Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals.

Evelyn Jagoda, Davide Marnetto, Gayani Senevirathne, Victoria Gonzalez, Kaushal Baid, Francesco Montinaro, Daniel Richard, Darryl Falzarano, Emmanuelle V LeBlanc, Che C Colpitts and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Archaic hominin admixture and its consequences for modern humans.Current opinion in genetics & development · 2025
    Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. rs71327024 Associated with COVID-19 Hospitalization ReducesInternational journal of molecular sciences · 2023
    Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 4 countries.

Evelyn Jagoda *Department of Human Evolutionary Biology, Harvard University, Cambridge, United States.
Davide Marnetto *Estonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Gayani SenevirathneDepartment of Human Evolutionary Biology, Harvard University, Cambridge, United States.
Victoria GonzalezDepartment of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada.
Kaushal BaidVaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada.
Francesco MontinaroEstonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Daniel RichardDepartment of Human Evolutionary Biology, Harvard University, Cambridge, United States.
Darryl FalzaranoDepartment of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada.
Emmanuelle V LeBlancDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.
Che C ColpittsDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.ORCID 0000-0003-2474-1834
Arinjay BanerjeeDepartment of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada.ORCID 0000-0002-2821-8357
Luca PaganiEstonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Terence D CapelliniDepartment of Human Evolutionary Biology, Harvard University, Cambridge, United States.ORCID 0000-0003-3842-8478
Harvard University · USUniversity of Saskatchewan · CAEstonian Biocentre · EEQueen's University · CABroad Institute · USUniversity of Padua · ITUniversity of Waterloo · CA

Funding

HSRD VA IIR 16-003
6 · The paper itself

Abstract

Individuals infected with the

Indexed as

COVID-19NeanderthalsVirus DiseasesAnimalsGenetics, PopulationHumansSARS-CoV-2CCR1CCR5cis-regulationCOVID-19evolutionary biologygeneticsgenomicshumanMPRANeandertal introgression

Identifiers

PMID36763080
PMCPMC9917435
OpenAlexW4319826367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.