Evidence map›Paper›PMID 36762848›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023

A Genetically Heterogeneous Rat Model with Divergent Mitochondrial Genomes.

Roshini Sathiaseelan, Bumsoo Ahn, Michael B Stout, Sreemathi Logan, Jonathan Wanagat, Hoang Van M Nguyen, Norman G Hord, Amy R Vandiver, Ramasamy Selvarani, Rojina Ranjit and 6 more

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In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Roshini SathiaseelanDepartment of Nutritional Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Bumsoo AhnGerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Michael B StoutAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
Sreemathi LoganDepartment of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Jonathan WanagatDivisions of Geriatrics and Dermatology, Department of Medicine, University of California Los Angeles and Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Hoang Van M NguyenDepartment of Nutritional Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Norman G HordDepartment of Nutritional Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Amy R VandiverDivisions of Geriatrics and Dermatology, Department of Medicine, University of California Los Angeles and Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Ramasamy SelvaraniDepartment of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Rojina RanjitDepartment of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Hannah YarbroughDepartment of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Anthony MasingaleDepartment of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Benjamin F MillerAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
Roman F WolfOklahoma City VA Medical Center, Oklahoma City, Oklahoma, USA.
Steven N AustadDepartment of Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Arlan RichardsonOklahoma City VA Medical Center, Oklahoma City, Oklahoma, USA.
University of Oklahoma Health Sciences Center · USOklahoma City VA Medical Center · USUniversity of California, Los Angeles · USUniversity of Alabama at Birmingham · USWake Forest University · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
Targeted DNA Methylation and Mitochondrial Heteroplasmy CoreP30AG050911 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI William Edmund Sonntag · 2015 to 2026
$13.9M
Role of estrogen receptor-a in aging and sex-specific responses to 17a-estradiolR01AG070035 · NIA · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI STOUT, MICHAEL B · 2021 to 2025
$2.6M
Mitochondrial DNA Deletion Mutation Frequency as a Metric of Biologic AgeR01AG069924 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jonathan Wanagat · 2022 to 2026
$2.1M
Mitochondrial biogenesis, genetics and cell loss in mammalian agingR01AG055518 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AIKEN, JUDD M., HERBST, ALLEN · 2017 to 2022
$2.0M
A sex difference approach to evaluating resilience as a predictor of healthspan in miceR01AG057434 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AUSTAD, STEVEN N., CARTER, CHRISTY SHAWN · 2017 to 2021
$1.5M
IGF-1 Regulation of Astrocyte Mitochondrial Metabolism and Redox Homeostasis in Brain AgingR00AG056662 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LOGAN, SREEMATHI · 2020 to 2022
$996k
The role of unacylated ghrelin on age-associated progressive muscle weakness and cachexia elicited by cancerR00AG064143 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI AHN, BUMSOO · 2022 to 2024
$839k
Mitochondrial biogenesis, genetics and cell loss in mammalian agingK02AG059847 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANAGAT, JONATHAN · 2018 to 2022
$801k
Mechanisms of metabolic, inflammatory and healthspan enhancement by 17a-estradiolR00AG051661 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI STOUT, MICHAEL B · 2018 to 2020
$746k
A New Translational Rat Model for Evaluating Anti-Aging InterventionsR21AG072137 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI AUSTAD, STEVEN N., RICHARDSON, ARLAN G. · 2022 to 2023
$415k
A Four Core Genotype (FCG) Approach to Investigating Sex Differences in Health and LongevityR21AG058811 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AUSTAD, STEVEN N. · 2018 to 2019
$408k
BLRD VA I01 BX004538BLRD VA IK6 BX005238NIA NIH HHS K02 AG059847NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG050911NIA NIH HHS R00 AG051661NIA NIH HHS R00 AG056662NIA NIH HHS R00 AG064143NIA NIH HHS R01 AG055518NIA NIH HHS R01 AG057434NIA NIH HHS R01 AG069924NIA NIH HHS R01 AG070035NIA NIH HHS R21 AG058811NIA NIH HHS R21 AG072137NIH HHS R21AG072137
6 · The paper itself

Abstract

We generated a genetically heterogenous rat model by a 4-way cross strategy using 4 inbred strains (Brown Norway [BN], Fischer 344 [F344], Lewis [LEW], and Wistar Kyoto [KY]) to provide investigators with a highly genetically diverse rat model from commercially available inbred rats. We made reciprocal crosses between males and females from the 2 F1 hybrids to generate genetically heterogeneous rats with mitochondrial genomes from either the BN (OKC-HETB, a.k.a "B" genotype) or WKY (OKC-HETW a.k.a "W" genotype) parental strains. These two mitochondrial genomes differ at 94 nucleotides, more akin to human mitochondrial genome diversity than that available in classical laboratory mouse strains. Body weights of the B and W genotypes were similar. However, mitochondrial genotype antagonistically affected grip strength and treadmill endurance in females only. In addition, mitochondrial genotype significantly affected multiple responses to a high-fat diet (HFD) and treatment with 17α-estradiol. Contrary to findings in mice in which males only are affected by 17α-estradiol supplementation, female rats fed a HFD beneficially responded to 17α-estradiol treatment as evidenced by declines in body mass, adiposity, and liver mass. Male rats, by contrast, differed in a mitochondrial genotype-specific manner, with only B males responding to 17α-estradiol treatment. Mitochondrial genotype and sex differences were also observed in features of brain-specific antioxidant response to a HFD and 17α-estradiol as shown by hippocampal levels of Sod2 acetylation, JNK, and FoxO3a. These results emphasize the importance of mitochondrial genotype in assessing responses to putative interventions in aging processes.

Indexed as

Genome, MitochondrialAnimalsEstradiolFemaleHumansMaleMiceRatsRats, Inbred F344Rats, Inbred LewRats, Inbred StrainsRats, Inbred WKYEstradiolAgingEstrogenGenetic diversityMitochondriaPhysical functionSex differences

Identifiers

PMID36762848
PMCPMC10172978
OpenAlexW4319826231

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.