Evidence map›Paper›PMID 36762438›Full record

ArticleEMBO reports2023

SPTing across condensates: SEC-mediated translocation of SPT complex from pausing condensates to elongation condensates.

Prashant Rawat, Ritwick Sawarkar

Abstract readComment
In one paragraph

Article in EMBO reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Liquid condensates: a new barrier to loop extrusion?Cellular and molecular life sciences : CMLS · 2025
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Prashant RawatInstitute of Biochemistry, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland.ORCID 0000-0002-4723-6323
Ritwick SawarkarMedical Research Council (MRC), Department of Genetics, University of Cambridge, Cambridge, UK.ORCID 0000-0003-0532-7662

Funding

Medical Research Council MC_UU_00025/8
6 · The paper itself

Abstract

Several independent studies in the last few years have suggested that phase separation and biomolecular condensation play a critical role in regulating different transcription steps from initiation to pausing and elongation. However, how components of the transcription machinery translocate among different types of condensates during transcription remains poorly understood. Guo et al have now identified a potential mechanism underlying translocation of the DSIF complex from pausing to elongation condensates during promoter pause release, as reported in this issue of EMBO reports.

Indexed as

RNA Polymerase IITranscription FactorsCell NucleusNuclear ProteinsTranscription, GeneticNuclear ProteinsRNA Polymerase IITranscription Factors

Identifiers

PMID36762438
PMCPMC9986807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.