Evidence map›Paper›PMID 36762366›Full record

ReviewDermatology research and practice2023

Suggested Guidelines for the Treatment of Mycosis Fungoides in Countries with Limited Resources.

Mona Abdel-Halim Ibrahim, Nada Eltayeb, Mirna Michel Ibrahim, Ahmed Nassar, Maged Daruish, Maha El-Zimaity, Mahmoud El-Lithy, Ahmed Mostafa, Amal El-Afifi, Haitham Abdelbary and 1 more

Abstract readReview
In one paragraph

Review in Dermatology research and practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Hypopigmented mycosis fungoides: an important differential diagnosis of hypochromias in childhood.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mona Abdel-Halim IbrahimDermatology Department, Ain-Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-1859-6442
Nada EltayebDermatology Department, Ain-Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-3935-8267
Mirna Michel IbrahimDermatology Department, Ain-Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-4723-6320
Ahmed NassarDermatology Department, Ain-Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-0958-890X
Maged DaruishDepartment of Dermatopathology, St. John's Institute of Dermatology Guy's and St. Thomas' Nhs Trust, London, UK.ORCID https://orcid.org/0000-0001-9090-6380
Maha El-ZimaityHematology Department, Ain-Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-2221-968X
Mahmoud El-LithyOncology Department, Ain-Shams University, Cairo, Egypt.
Ahmed MostafaOncology Department, Ain-Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-2926-6502
Amal El-AfifiHematology Department, Ain-Shams University, Cairo, Egypt.
Haitham AbdelbaryHematology Department, Ain-Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-0962-9289
Mahira Hamdy El-SayedDermatology Department, Ain-Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-8742-5401

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment options for mycosis fungoides (MF) have been expanding but unfortunately many of the currently used treatment modalities are unavailable in Egypt and other African/Arab countries. In addition, there is a lack of consensus on the treatment of hypopigmented MF (HMF), which is a frequently encountered variant in our population. We aimed to develop regional treatment guidelines based on the international guidelines but modified to encompass the restricted treatment availability and our institutional experience. Special attention was also given to studies conducted on patients with skin phototype (III-IV). Treatment algorithm was formulated at Ain-Shams cutaneous lymphoma clinic through the collaboration of dermatologists, haematologists, and oncologists. Level of evidence is specified for each treatment option. For HMF, phototherapy is recommended as a first line treatment, while low-dose methotrexate is considered a second line. For early classical MF, we recommend Psoralen-ultraviolet A (PUVA), which is a well-tolerated treatment option in dark phenotype. Addition of either retinoic acid receptor (RAR) agonist and/or methotrexate is recommended as a second line. Total skin electron beam (TSEB) is considered a third-line option. For advanced stage, PUVA plus RAR agonist and/or methotrexate is recommended as first line, TSEB or monochemotherapy is considered a second line option. Polychemotherapy is regarded as a final option. All patients with complete response (CR) enter a maintenance and follow-up schedule. We suggest a practical algorithm for the treatment of MF for patients with dark phenotype living in countries with limited resources.

Identifiers

PMID36762366
PMCPMC9904957

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.