Evidence map›Paper›PMID 36762299›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Rural residence across the life course and late-life cognitive decline in KHANDLE: A causal inference study.

Rachel L Peterson, Paola Gilsanz, Yi Lor, Kristen M George, Michelle Ko, Jenny Wagner, Yenee Soh, Oanh L Meyer, M Maria Glymour, Rachel A Whitmer

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Young adult urbanicity, late midlife neighborhood disadvantage, and cognitive functioning in community-dwelling older men.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
  3. Article
  4. Article
  5. Lifespan exposures to rural-urban conditions and later-life cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Rachel L PetersonSchool of Public and Community Health Sciences University of Montana Missoula Montana USA.
Paola GilsanzDivision of Research Kaiser Permanente Northern California Oakland California USA.
Yi LorDepartment of Public Health Sciences University of California Davis Davis California USA.
Kristen M GeorgeDepartment of Public Health Sciences University of California Davis Davis California USA.
Michelle KoDepartment of Public Health Sciences University of California Davis Davis California USA.
Jenny WagnerDepartment of Public Health Sciences University of California Davis Davis California USA.
Yenee SohDivision of Research Kaiser Permanente Northern California Oakland California USA.
Oanh L MeyerDepartment of Neurology University of California Davis Sacramento California USA.
M Maria GlymourDepartment of Epidemiology and Biostatistics University of California San Francisco San Francisco California USA.
Rachel A WhitmerDepartment of Public Health Sciences University of California Davis Davis California USA.
University of California, Davis · USKaiser Permanente · USUniversity of California, San Francisco · USUniversity of Montana · US

Funding

Lifecourse health, cerebral pathology and ethnic disparities in dementia (KHANDLE Study)R01AG052132 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GILSANZ, PAOLA, GLYMOUR, MEDELLENA MARIA · 2021 to 2025
$18.0M
Lifecourse exposure to community violence and risk of cognitive decline, Alzheimer's Disease, and related dementias among African-AmericansR01AG067525 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KO, MICHELLE JASSMINE · 2020 to 2024
$2.3M
Contributions of educational quality and occupational complexity on racial and ethnic inequities in brain health and Alzheimer's disease and related dementiaR01AG066132 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI GILSANZ, PAOLA · 2019 to 2023
$2.0M
Lifecourse Community Contexts and Health Behaviors as Drivers of Disparities in Risk of Alzheimer's Disease and Related DementiasR00AG073457 · NIA · UNIVERSITY OF MONTANA · PI PETERSON, RACHEL LYNNE · 2022 to 2024
$724k
NIA NIH HHS R00 AG073457NIA NIH HHS R01 AG052132NIA NIH HHS R01 AG066132NIA NIH HHS R01 AG067525
6 · The paper itself

Abstract

Background: Modifiable risks for dementia are more prevalent in rural populations, yet there is a dearth of research examining life course rural residence on late-life cognitive decline. Methods: The association of rural residence and socioeconomic status (SES) in childhood and adulthood with late-life cognitive domains (verbal episodic memory, executive function, and semantic memory) and cognitive decline in the Kaiser Healthy Aging and Diverse Life Experiences cohort was estimated using marginal structural models with stabilized inverse probability weights. Results: After adjusting for time-varying SES, the estimated marginal effect of rural residence in childhood was harmful for both executive function ( Conclusions: Childhood rurality is associated with poorer late-life cognition independent of SES.

Indexed as

cognitive agingcohort studyepidemiologyhealth disparities

Identifiers

PMID36762299
PMCPMC9896964
OpenAlexW4319079809

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.